Chemistry of Natural Compounds

, Volume 19, Issue 1, pp 70–73 | Cite as

Use of 2-alkoxy-1-alkoxycarbonyl-1,2-dihydroquinolines as condensing agents in the synthesis of intermediate fragments of the 1–4 sequence of ACTH

  • A. A. Antonov
  • E. P. Krysin
  • V. N. Karel'skii
  • L. N. Astashkina


The use of 2-alkoxy-l-alkoxycarbonyl-1,2-dihydroquinolines as a condensing agent in a number of stages in the synthesis of fragments of the 1–4 sequence of ACTH is considered. In a number of cases, these compounds have successfully replaced dicyclohexylcarbodiimide, which is a strong allergen. All the compounds described were obtained in satisfactory yields and had fairly high purities. They were characterized from their angles of optical rotation, chromatographic mobilities, and melting points. The conditions for performing the reaction and some physicochemical characteristics of the compounds synthesized are presented.


Organic Chemistry Melting Point High Purity Physicochemical Characteristic Optical Rotation 
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Literature cited

  1. 1.
    D. Belleau and G. Malek, J. Am. Chem. Soc.,90, 1651 (1968).Google Scholar
  2. 2.
    Y. Kiso and H. Yajima, Chem. Commun., 942 (1972).Google Scholar
  3. 3.
    L. Fieser and M. Fieser, Reagents for Organic Solvents, Wiley, New York.Google Scholar
  4. 4.
    US Patent No. 3,247,180; R. Iselin and R. Schwyzer, Helv. Chim. Acta,44, 165 (1961); H. Otsuka et al., Bull. Chem. Soc. Jpn.,39, No. 6, 1171 (1966).Google Scholar
  5. 5.
    S. V. Rogozhin, A. I. Yurtanov, et al., Izv. Akad. Nauk SSSR, Ser. Khim., 1868 (1974).Google Scholar

Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • A. A. Antonov
  • E. P. Krysin
  • V. N. Karel'skii
  • L. N. Astashkina

There are no affiliations available

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