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Chemistry of Natural Compounds

, Volume 19, Issue 1, pp 46–52 | Cite as

Complexes of cholesterol with carboxylic acids and their amides

  • D. V. Ioffe
  • I. M. Ginzburg
Article

Abstract

It has been shown by IR spectroscopy that in dilute solutions of equimolar mixtures of cholesterol and carboxylic acids binary complexes, each with a hydrogen bond, in which the cholesterol is the acceptor and the acid the donor of a proton, are formed. With an increase in concentration, these complexes form aggregates through two types of hydrogen bond between the activated hydroxyl of the cholesterol and the oxygen atom of the C=0 or the OH group of the acid. In crystalline complexes of cholesterol with carboxylic acids, only COOH...OH...O=C hydrogen bonds are realized. It has been concluded that for the formation of a crystalline complex with cholesterol the second component must be both an acceptor and a donor of a proton in a H bond. This conclusion has been confirmed by the preparation of crystalline complexes with primary and secondary amides.

Keywords

Oxygen Hydrogen Cholesterol Hydroxyl Hydrogen Bond 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • D. V. Ioffe
  • I. M. Ginzburg

There are no affiliations available

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