Chemistry of Natural Compounds

, Volume 19, Issue 1, pp 46–52 | Cite as

Complexes of cholesterol with carboxylic acids and their amides

  • D. V. Ioffe
  • I. M. Ginzburg


It has been shown by IR spectroscopy that in dilute solutions of equimolar mixtures of cholesterol and carboxylic acids binary complexes, each with a hydrogen bond, in which the cholesterol is the acceptor and the acid the donor of a proton, are formed. With an increase in concentration, these complexes form aggregates through two types of hydrogen bond between the activated hydroxyl of the cholesterol and the oxygen atom of the C=0 or the OH group of the acid. In crystalline complexes of cholesterol with carboxylic acids, only COOH...OH...O=C hydrogen bonds are realized. It has been concluded that for the formation of a crystalline complex with cholesterol the second component must be both an acceptor and a donor of a proton in a H bond. This conclusion has been confirmed by the preparation of crystalline complexes with primary and secondary amides.


Oxygen Hydrogen Cholesterol Hydroxyl Hydrogen Bond 
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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • D. V. Ioffe
  • I. M. Ginzburg

There are no affiliations available

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