Chemistry of Natural Compounds

, Volume 19, Issue 3, pp 320–325 | Cite as

Interaction of cardenolides of the strophanthidin series with functionally important sections of transport Na,K-ATPase

  • N. M. Mirsalikhova
Article
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Abstract

On the basis of an analysis of the structure-activity interrelationship of cardiac glycosides and their analogs, four-center model of the binding of the compounds with Na,K-ATPase has been proposed. These centers are represented by the steroid nucleus with a polar group at C-3 and a hydroxy group at C-14, and also by a lactone ring with a double bond. It has been shown that the hydrophobic binding section of the glycoside must be in contact with a hydrophobic region of the enzyme having a fairly large volume.

Keywords

Steroid Organic Chemistry Double Bond Large Volume Glycoside 

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Copyright information

© Plenum Publishing Corporation 1983

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  • N. M. Mirsalikhova

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