Stability of aztreonam in a portable pump reservoir used for home intravenous antibiotic treatment (HIVAT)


The stability of the monocyclic β-lactam antibiotic aztreonam in portable pump reservoirs was studied during storage at temperatures of-20°C and +5°C and during drug delivery at 37°C. Three 100-ml drug reservoirs and three glass containers containing 60 mg/ml aztreonam were stored at-20°C and 2-ml samples were analysed in the freshly prepared solution and after thawing at days 7, 21, 28, 70 and after 6 months of storage. A separate triplicate batch of 100-ml prefilled drug reservoirs and glass containers containing a similar aztreonam concentration (60 mg/ml) were refrigerated and tested immediately after preparation and daily for 8 days and after 70 days. Solutions of aztreonam in duplicate freshly prepared reservoirs were tested for stability when the solution was pumped at 37°C over a 24-h period. All solutions were inspected for visual changes and tested for pH. Drug concentration was analysed by high-performance liquid chromatography. No colour changes or pH differences were observed in any of the solutions in the reservoirs or containers. No statistically significant decrease in aztreonam concentration could be detected after 6 months of storage at-20°C. Aztreonam was stable at 5°C for at least 8 days. A 24-h pumping period at 37°C showed a 3.6% decrease in aztreonam concentration. Aztreonam at a concentration of 60 mg/ml in a pump reservoir is sufficiently stable to be used in home intravenous antibiotic treatment programmes.

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  1. 1

    Williams DN, Gibson JA, Bosch D. Home intravenous antibiotic therapy using a programmable pump. Arch Intern Med 1989;149:1157–60.

    Google Scholar 

  2. 2

    CADD-PLUS Ambulatory Infusion Pump. A Pharmacy Handbook of Drug Delivery Application. Pharmacia Deltec Inc, St. Paul, Minnesota, USA, 1991.

  3. 3

    Bakker W, Vinks AATMM, Mouton JW, de Jonge P, Verzijl JG, Heijerman HGM. Continuous intravenous treatment at home of respiratory tract infections with ceftazidime using a portable pump in cystic fibrosis patients; a multicentre study. Ned Tijdschr Geneesk 1993;137:2486–91.

    Google Scholar 

  4. 4

    Vinks AATMM, Touw DJ, Heijerman HGM, Danhof M, de Leede GPJ, Bakker W. Pharmacokinetics of ceftazidime in adult cystic fibrosis patients during continuous infusion and ambulatory treatment at home. Ther Drug Monit 1994;16:341–8.

    Google Scholar 

  5. 5

    Tunkel AR, Scheld WM. Clinical pharmacology of antibiotics: Aztreonam. Inf Control Hosp Epidemiol 1990;11:486–94.

    Google Scholar 

  6. 6

    Fiel SB. Clinical management of pulmonary disease in cystic fibrosis. Lancet 1993;341:1070–4.

    Google Scholar 

  7. 7

    Roos PJ, Glerum JH, Meilink. Stability of morphine hydrochloride in a portable pump reservoir. Pharm Weekbl Sci 1992;14:23–6.

    Google Scholar 

  8. 8

    Florey K. Aztreonam. In: Florey K, editor. Analytical profiles of drug substances. Vol 17. San Diego: Academic Press, 1988;3–39.

    Google Scholar 

  9. 9

    Trissel LA. Handbook on injectable drugs. 8th ed. Bethesda, MD: American Society of Hospital Pharmacists, 1994:108–11.

    Google Scholar 

  10. 10

    James JJ, Riley CM. Stability of intravenous admixtures of aztreonam and ampicillin. Am J Hosp Pharm 1985;42:1095–100.

    Google Scholar 

  11. 11

    Marble DA, Bosso JA, Townsend RJ. Stability of clindamycin phosphate with aztreonam, ceftazidime sodium, ceftriaxone sodium, or piperacillin sodium in two intravenous solutions. Am J Hosp Pharm 1986;43:1732–6.

    Google Scholar 

  12. 12

    Belliveau PP, Nightingale CH, Quintiliani. Stability of aztreonam and ampicillin sodium-sulbactam sodium in 0.9% sodium chloride. Am J Hosp Pharm 1994;51:901–4.

    Google Scholar 

  13. 13

    Jehl F, Gallion C, Monteil H. High-performance chromatography of antibiotics. J Chromatogr (Biomed Appl) 1990;531:509–48.

    Google Scholar 

  14. 14

    Van der Vaart FJ. Guideline for analytical validation. Report of the Dutch working party on quality assurance in pharmaceutical analysis. Pharm Weekbl 1992;127:1229–35.

    Google Scholar 

  15. 15

    Touw DJ, Trumpie HCW. Validation in bioanalysis. A practical example. Pharm Weekbl 1995;130:227–32.

    Google Scholar 

  16. 16

    Beijnen JH, Branje JPA, van Niel JCC, Touw DJ. Protocol stabiliteitsonderzoek van geneesmiddelen in waterige oplossing [Protocol for investigating the stability of drugs in aqueous solution]. 's-Gravenhage: Nederlandse Vereniging van Ziekenhuisapothekers, 1993.

    Google Scholar 

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Vinks, A.A.T.M.M., Touw, D.J., van Rossen, R.C.J.M. et al. Stability of aztreonam in a portable pump reservoir used for home intravenous antibiotic treatment (HIVAT). Pharm World Sci 18, 74–77 (1996).

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  • Aztreonam
  • Infusion pump, external
  • Drug stability