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Medical Microbiology and Immunology

, Volume 182, Issue 5, pp 233–242 | Cite as

Ultrastructural localization of urease ofHelicobacter pylori

  • G. Bode
  • P. Malfertheiner
  • G. Lehnhardt
  • M. Nilius
  • H. Ditschuneit
Original Investigations

Abstract

Helicobacter pylori urease was characterized by means of an enzyme histochemical electron microscopic technique. Ultrastructural analysis revealed no urease activity in one strain; in sevenH. pylori strains (43.75%), urease activity was associated with the cell membrane. Eight strains (50.0%) showed reaction product located within the cytoplasm. Urease activity showed no correlation with localization of activity. Our results demonstrate thatH. pylori urease is not uniform in allH. pylori strains, and differences in activity and localization of urease activity may account for different virulence activities.

Keywords

Cell Membrane Microscopic Technique Urease Activity Ultrastructural Analysis Pylorus Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • G. Bode
    • 1
  • P. Malfertheiner
    • 1
  • G. Lehnhardt
    • 1
  • M. Nilius
    • 1
  • H. Ditschuneit
    • 1
  1. 1.Department of Internal Medicine IUniversity of UlmUlmGermany

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