Synthesis of the hexapeptide 11–16 of the natural sequence of human calcitonin
A new variant of the preparative synthesis of hexapeptide 11–16 of the natural sequence of human calcitonin is described. In several of the stages 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline was used successfully as the condensing agent. The final and intermediate compounds were obtained with good yields in chromatographically homogeneous form. Their purity was checked by TLC and measurements of angles of optical rotation. The final product was identified additionally by13C NMR. Several physicochemical characteristics of the compounds synthesized (angles of optical rotation, chromatographic mobilities) are given.
KeywordsDipeptide Optical Rotation DMFA Natural Sequence Cysteic Acid
Unable to display preview. Download preview PDF.
- 2.W. Rittel, Swiss Patent No. 550,774, cl. C07 c 103/52, published October 15, 1968; S. Nozaki, Bull. Chem. Soc. Jpn.,51, No. 10, 2995 (1978).Google Scholar
- 3.A. A. Antonov, E. P. Krysin, V. N. Karel'skii, and L. N. Astashkina, Khim. Prir. Soedin., 74 (1983).Google Scholar
- 4.V. I. Svergun, M. B. Smirnov, V. N. Karel'skii, V. P. Panov, and E. P. Krysin. Khim.-Farm. Zh., No. 6, 97 (1978).Google Scholar