Biosynthesis of asterosaponins from cholesterol and other sterols under the conditions ofin vitro homogenates of starfish gonads and pyloric ceca
Conditions have been selected for performing thein vitro biosynthesis of asterosaponins from cholesterol and other sterols in homogenates and cultures of the gonads and pyloric ceca of Far Eastern starfish. It has been shown that the aglycone moiety of an asterosaponin can be biosynthesized from cholesterol, cholesterol sulfate, 5α-cholestanol, and 3β,6α-dihydroxy-5α-cholestane but not from 3β, 6β-dihydroxy-5α-cholestane. Of the give precursors studied, cholesterol was transformed into asterosaponins most completely.
KeywordsCholesterol DNPH Diborane Mevalonic Acid POPOP
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- 1.K. Okano, T. Nakamura, Y. Kamiya, and S. Ikegami, Agric. Biol. Chem.,45, No. 3, 805 (1981).Google Scholar
- 2.A. M. Mackie, H. T. Singh, and J. M. Owen, Comp. Biochem. Physiol.,56B, 9 (1977).Google Scholar
- 3.W. J. Fleming, R. Salathe, S. V. Wylie, and M. E. Howden, Comp. Biochem. Physiol.,53B, 267 (1976).Google Scholar
- 5.G. B. Elyakov, E. V. Levina, V. S. Levin, and I. I. Kapustina, Comp. Biochem. Physiol.,55B, 57 (1975).Google Scholar
- 6.I. I. Kapistina, É. V. Levina, and V. A. Stonik, Khim. Prir. Soedin., 411 (1978).Google Scholar
- 8.L. Fieser and M. Fieser, Reagents for Organic Synthesis, Wiley, New York (1967).Google Scholar
- 9.Weygand/Hilgetag's Preparative Organic Chemistry, Wiley, New York (1972) [Russian translation (from the German)], Moscow (1968), p. 475.Google Scholar