Mycopathologia

, Volume 120, Issue 1, pp 23–28 | Cite as

Immunodeficiency secondary to juvenile paracoccidioidomycosis: associated infections

  • M. A. Shikanai-Yasuda
  • A. A. Cotrim Segurado
  • W. Pereira Pinto
  • A. C. Nicodemo
  • M. Sato
  • A. J. S. Duarte
  • G. B. Del Negro
  • R. U. Hutzler
  • M. Shiroma
  • V. A. Neto
Human and Animal Mycology

Abstract

Four patients with acute paracoccidioidomycosis, hypoalbuminemia, ascites and associated infections are reported. They have been admitted to hospital 35 times, 4 of them due to active paracoccidioidomycosis, 14 to associated infections, 14 to ascites, edema and diarrhoea and 3 to herniorraphy. Two of them recovered after sepsis and central nervous system, muscular and subcutaneous cryptococcosis. The remaining two died. One had infectious diarrhoea (S. flexneri), peritoneal tuberculosis and sepsis (S. epidermidis); the other had bacterial meningitis, erysipelas, beta-hemolyticStreptococcus sepsis and miliary tuberculosis. Their immunodeficiency was attributed to enteric protein loss and/or malabsorption and malnutrition and was recognized by reduced response to delayed hypersensitivity skin tests in four patients and hypogammaglobulinemia in three of them. The authors discuss the need for prospective studies to be carried out, aiming at the mechanisms involved in secondary infections. Alternatives for maintaining the patients' adequate nutritional state should be investigated, to guarantee proper immune response and thus the ability to control intervening infections in patients with juvenile paracoccidioidomycosis.

Key words

Paracoccidioidomycosis secondary immunodeficiency lymphatic block intestinal protein loss 

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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • M. A. Shikanai-Yasuda
    • 1
    • 2
  • A. A. Cotrim Segurado
    • 1
  • W. Pereira Pinto
    • 1
  • A. C. Nicodemo
    • 1
  • M. Sato
    • 3
  • A. J. S. Duarte
    • 3
  • G. B. Del Negro
    • 4
  • R. U. Hutzler
    • 1
  • M. Shiroma
    • 1
  • V. A. Neto
    • 1
  1. 1.Department of Infectious and Parasitic Diseases, Faculty of MedicineUniversity of Sao PauloBrazil
  2. 2.Medical Inv. Laboratory ImmunologyBrazil
  3. 3.Medical Inv. Laboratory in Immunogenetics and Experimental TransplantationBrazil
  4. 4.Medical Inv. Laboratory in Medical Micology of Hospital das Clínicas, Faculty of MedicineUniversity of São PauloBrazil

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