Biochemical Genetics

, Volume 29, Issue 1–2, pp 55–63 | Cite as

Genetic characterization of esterase 28 (ES-28) of the house mouse

  • Otto H. von Deimling
  • Bernd Wassmer


The genetics of esterase-28, the major esterase of cauda epididymidis of the house mouse, has been studied after separation by polyacrylamide gel electrophoresis and isoelectric focusing. Four phenotypes are distinguished. Segregation ofEs-28 in two backcross series indicated linkage to Es-1, Es-9, and Es-22. The Es-28 locus was placed into esterase cluster 1 on chromosome 8.

Key words

Mus esterase-28 epididymis chromosome 8 


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  1. Biddle, F. (1987). Segregation distortion of X-linked marker genes in interspecific crosses betweenM. musculus andM. spretus.Genome 29389.Google Scholar
  2. Böcking, A., Hansert, J., and Deimling, O. (1976). Esterase XXII: Cellular and subcellular localization of the Es-9 esterase in mouse kidney.Histochemistry 46177.Google Scholar
  3. Britten, R. (1986). Rates of DNA sequence evolution differ between taxonomic groups.Science 2311393.Google Scholar
  4. Deimling, O. (1985). Esterasen der Ratte (R. norveg.): Biochemische und evolutionäre Aspekte.Dtsch. tierärztl. Wschr. 92482.Google Scholar
  5. Deimling, O., and Wassmer, B. (1990). Genetic identification of non-specific esterases of the mouse cauda epididymidis and description of esterase-28, a new carboxylesterase isoenzyme (EC Reprod. Fert. 8841–50.Google Scholar
  6. De Looze, S. M., Ronai, A., and Deimling, O. (1983). Clofibrate-induced decrease in esterase 1 levels in the serum of the house mouse,Mus musculus.Biochem. Pharmacol. 322124.Google Scholar
  7. Documenta Geigy (1962)Wissenschaftliche Tabellen Geigy, Basel, pp 85–98.Google Scholar
  8. Gomori, G. (1952). Histochemistry of esterase.Int. Rev. Cytol. 1323.Google Scholar
  9. Green, M. C. (1989). Catalog of mutant genes and polymorphic loci. In Lyon, M., and Searle, A. G. (eds.),Genetic Variants and Strains of the Laboratory Mouse 2nd ed., Oxford University Press, Oxford, New York, Tokyo, Gustav Fischer Verlag, Stuttgart, pp. 12–403.Google Scholar
  10. Lipps, A., Ronai, A., and Deimling, O. (1979). Esterase-7, a common constituent of numerous mouse tissues.Comp. Biochem. Physiol. 62B201.Google Scholar
  11. McGadey, J. (1967). Modified indoxyl acetate technique for the histochemical demonstration of non-specific esterases in mouse testis.J. Med. Lab. Tech. 24126.Google Scholar
  12. Medda, S., Deimling, O., and Swank, R. T. (1986). Identity of egasyn, the protein which complexes with microsomal β-glucuronidase, and esterase-22.Biochem. Genet. 24229.Google Scholar
  13. Nash, H. R., and Deimling, O. (1982). Kidney esterase of Mus musculus: Further polymorphism of esterase-6, esterase-9 and a new esterase, esterase-20.Biochem. Genet. 20537.Google Scholar
  14. Pearse, A. G. E. (1972).Histochemistry. Theoretical and Applied, Vol. 2 3rd ed., Churchill, Livingstone, Edinburgh and London.Google Scholar
  15. Scherer, G., Bausch, E., Gaa, A., and Deimling, O. (1989). Gene mapping on mouse chromosome 8 by interspecific crosses: New data on a linkage group conserved on human chromosome 16q.Genomics 5275.Google Scholar
  16. Womack, J. E., and Sharp, M. (1976). Comperative autosomal linkage in mammals: Genetics of esterase in Mus musculus and Rattus norvegicus.Genetics 82665.Google Scholar

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Otto H. von Deimling
    • 1
  • Bernd Wassmer
    • 1
  1. 1.Pathologisches Institut, Abteilung für Chemische PathologieUniverstität FreiburgFreiburg i.Br.Bundestrepublik Deutschland

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