Induction of bone, cartilage and hemopoietic tissue by subcutaneously implanted tissue diaphragms

  • Hans Selye
  • Yvette Lemire
  • Eörs Bajusz


The subcutaneous implantation of appropriate tissue diaphragms (short, broad glass cylinders) rather regularly induces the formation of bones provided with marrow cavities and junction cartilage plates, in the rat.

Bone formation, unlike the development of hemopoietic tissue, can be prevented, under these circumstances, by topical blockade of the phagocyte system with carbon particles.

The role of nonspecific topical stress factors, in the induction of such highly specific structural transformations, has been discussed.


Bone Formation Developmental Biology Stress Factor Structural Transformation Carbon Particle 
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  1. Huggins, C. B.: The formation of bone under the influence of epithelium of the urinary tract. Arch. Surg. (Chicago)22, 377 (1931).Google Scholar
  2. Selye, H.: The part of inflammation in the local adaptation syndrome. InG. Jasmin andA. Robert, The mechanism of inflammation. An International symposium. Acta, Inc., Med. Publs., Montreal, p. 77, 1953.Google Scholar
  3. —: The stress of life. New York: McGraw-Hill Book Comp. 1956.Google Scholar
  4. —: Translated into German under the title of: Stress beherrscht unser Leben. Düsseldorf: Econ-Verlag 1957.Google Scholar
  5. —: Gewebsdiaphragmen zum Studium der Physiopathologie des Kollagens. Medizinische1959a, Nr 14, 617.Google Scholar
  6. - Diaphragms for the analysis of the mechanics of connective tissue growth. Nature (Lond.) (in press 1959b).Google Scholar
  7. —: Grundlagen der Stressforschung. Wien. med. Wschr.109, 397 (1959c).Google Scholar
  8. Selye, H., P. Jean, M. Cantin andY. Lemire: Induction of adipose tissue development by mechanical means. Plast. reconstr. Surg.24, 250 (1959).Google Scholar
  9. Selye, H., P. Prioreschi andP. Jean: Water fixation as the immediate cause of tissue growth. Growth23, 169 (1959).Google Scholar

Copyright information

© Springer-Verlag 1960

Authors and Affiliations

  • Hans Selye
    • 1
  • Yvette Lemire
    • 1
  • Eörs Bajusz
    • 1
  1. 1.Institut de Médicine et de Chirurgie expérimentalesUniversité de MontréalMontrealCanada

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