The clinical investigator

, Volume 72, Issue 12, pp 1048–1050 | Cite as

Cryoglobulinemia: A complication of infectious disease

  • O. Witzke
  • J. Kassubek
  • E. Bonmann
  • E. Musch
Case Reports


We report on a 23-year-old male patient with general weakness, subfebrile temperatures, and arthralgia. The first symptoms were observed some months after a severe cytomegalovirus mononucleosis-gastroenteritis. High titers of cryoglobulins suggested an autoimmunological process. This case is interesting because of the association between cytomegalovirus infection and cryoglobulinemia. In conclusion, the differential diagnosis of autoimmune disease should be considered in the course of viral infections.

Key words

Cryoglobulinemia Cytomegalovirus Autoimmune disease 





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  1. 1.
    Berlin BS, Chandler R, Green D (1977) Anti “i” antibody and hemolytic anemia associated with spontaneous cytomegalovirus mononucleosis. Am J Clin Pathol 67:459Google Scholar
  2. 2.
    Bombardieri S et al. (1979) Lung involvement in essential mixed cryoglobulinemia. Am J Med 66:748Google Scholar
  3. 3.
    Brouet JC et al. (1973) Biological and clinical significance of cryoglobulins. Am J Med 57:775Google Scholar
  4. 4.
    Carney WP, Hirsch MS (1981) Mechanism of immunosupression in cytomegalovirus mononucleosis. II. Virus-monocyte interactions. J Infect Dis 144:47Google Scholar
  5. 5.
    Cordonnier DJ et al. (1987) The kidney in mixed cryoglobulinemia. Springer Semin Immunopathol 9:395Google Scholar
  6. 6.
    D'Amico G et al. (1988) Renal involvement in essential mixed cryoglobulinemia. Adv Nephrol 17:219Google Scholar
  7. 7.
    Dumonde DC, Steward MW (1978) The role of microbial infection in rheumatic disease. In: Scott IT (ed) Copeman's textbook of rheumatic disease, 5th edn. Churchill Livingstone, Edinburgh, p 222–258Google Scholar
  8. 8.
    Gorevic PD et al. (1980) Mixed cryoglobulinemia. Clinical aspects and long-term follow-up of 40 patients. Am J Med 69:287Google Scholar
  9. 9.
    Grey HM, Kohler PIT (1973) Cryoimmunoglobulins. Semin Hematol 10:87Google Scholar
  10. 10.
    Horwitz CA, Henle W Henle G (1979) Diagnostic aspects of the cytomegalovirus mononucleosis syndrome in previously healthy persons. Postgrad Med 66:153Google Scholar
  11. 11.
    Hughes GRV et al. (1986) The anticardiolipin syndrom. J Rheumatol 13:486Google Scholar
  12. 12.
    Kantor GL et al. (1970) Immunologic abnormalities induced by posttransfusion cytomegalovirus infection. Ann Intern Med 73:553Google Scholar
  13. 13.
    Me Leod BC, Sassetti RJ (1980) Plasmapheresis with return of cryoglobulin-depleted autologous plasma (cryoglobulinpheresis) in cryoglobulinemia. Blood 55:866Google Scholar
  14. 14.
    Moroz LA, Rose B (1977) The cryopathies. In: Samter M (ed) Immunological diseases. 2nd edn. Little, Brown & Co, BostonGoogle Scholar
  15. 15.
    Ristow SC et al. (1976) Reversal of systemic manifestations of cryoglobulinemia. Treatment with melphalan and prednisone. Arch Intern Med 136:467Google Scholar
  16. 16.
    Wager O, Rasanen JA, Hagman A, Klemola E (1968) Mixed cryoglobulinemia in infectious mononucleosis and cytomegalovirus mononucleosis. Int Arch Allergy 34:345Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • O. Witzke
    • 1
  • J. Kassubek
    • 1
  • E. Bonmann
    • 1
  • E. Musch
    • 1
  1. 1.Abteilung für Innere Medizin IIMarienhospitalBottropGermany

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