Studies on some aspects of regeneration inPelmatohydra oligactis

  • Leela Mulherkar
  • Gajanan V. Sherbet
  • K. Vasudeva Rao


  1. 1.

    A histological and experimental study undertaken to elucidate the mechanism of regeneration ofPelmatohydra oligactis has shown that there is no significant mitotic activity in regeneration.

  2. 2.

    Chloroacetophenone (CAP) caused inhibition of regeneration but cystine and cysteine were ineffective.

  3. 3.

    The results are discussed from the point of view of the importance of -SH⇌ -SS- equilibrium in regeneration. It is suggested that CAP might be acting on enzymatic -SH groups that are vitally concerned in some energy system.



Experimental Study Cysteine Developmental Biology Cystine Energy System 
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  1. Beatty, R. A.: Effect of chloroacetophenone and di-isopropyl fluorophosphonate on amphibian eggs. Proc. roy. Soc. B138, 575–600 (1951).Google Scholar
  2. Brachet, J.: Chemical Embryology. New York: Interscience Publishers 1950.Google Scholar
  3. —: Thiol groups and morphogenesis. Nature (Lond.)184, 1074–1075 (1959a).Google Scholar
  4. —: The effect of various metabolites and antimetabolites on the regeneration of fragments ofAcetabularia mediterranea. Exp. Cell Res.14, 650–651 (1959b).Google Scholar
  5. —: The role of ribonucleic acid and sulphydryl groups in morphogenesis. In: Growth in living systems. Ed.:M. X. Zarrow. New York: Basic Books Inc. Publishers 1961.Google Scholar
  6. Burnett, A. L.: Histophysiology of growth in hydra. J. exp. Zool.140, 281–341 (1959).PubMedGoogle Scholar
  7. Descotils-Heernu, F., J. Quertier etJ. Brachet: Quelques effets du β-mercaptoéthanol et du dithioglycol sur le régénération. Develop. Biol.3, 277–296 (1961).PubMedGoogle Scholar
  8. Dixon. M., andD. M. Needham: Biochemical research in chemical warfare agents. Nature (Lond.)158, 432 (1946).Google Scholar
  9. Dustin, P.: Some new aspects of mitotic poisoning. Nature (Lond.)159, 794–797 (1947).Google Scholar
  10. Ham, R. G., andR. E. Eaken: The time sequence of certain physiological events during regeneration. J. exp. Zool.139, 33–53 (1958a).PubMedGoogle Scholar
  11. — —: Loss of regeneration capacity in hydra treated with lipoic acid. J. exp. Zool.139, 55–68 (1958b).PubMedGoogle Scholar
  12. —,D. C. Fitzgerald andR. E. Eakin: Effects of lithium ion on regeneration of hydra in a chemically defined medium. J. exp. Zool.133, 559–572 (1956).Google Scholar
  13. Mackworth, J. F.: The inhibition of thiol enzymes by lachrymators. Biochem. J.42, 82–90 (1948).Google Scholar
  14. Mookerjee, S., andA. Sinha: Regionally in the inductive power of hydra tentacle. J. exp. Zool.141, 379–388 (1959).PubMedGoogle Scholar
  15. Moore (Singer), J.: Interstitial cells in the regeneration ofCordylophora lacustris. Quart. J. micr. Sci.3, 269–288 (1952).Google Scholar
  16. Rowley, H. T.: Histological changes inHydra viridis during regeneration. Amer. Nat.36, 579–583 (1902).Google Scholar
  17. Spangenberg, D. B., andR. E. Eakin: The effect of lipoic acid on regeneration ofCordylophora viridissima. J. exp. Zool.147, 211–217 (1961a).PubMedGoogle Scholar
  18. — —: A study of variation in the regeneration of hydra. J. exp. Zool.147, 259–270 (1961b).PubMedGoogle Scholar
  19. Sturtevant Jr., F. M., R. P. Sturtevant andC. I. Turner: Effect of colchicine on regeneration inPelmatohydra oligactis. Science114, 241–242 (1951).PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1963

Authors and Affiliations

  • Leela Mulherkar
    • 1
  • Gajanan V. Sherbet
    • 1
  • K. Vasudeva Rao
    • 1
  1. 1.Department of ZoologyUniversity of PoonaPoona 7

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