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Chemistry of Natural Compounds

, Volume 19, Issue 5, pp 572–576 | Cite as

Oximes and nitriles of cardenolides

  • I. F. Makarevich
  • M. V. Mokrouz
  • L. Ya. Topchii
  • I. P. Kovalev
  • V. E. Sokolova
  • Yu. I. Gubin
  • N. P. Bublik
  • V. A. Polyakov
Article
  • 23 Downloads

Abstract

The influence of the oximation of cardenolides and the production of 10-cyanocardenolides on their biological activity has been studied. The prefered conformation of strophanthidin 19-aldoxime has been established; it has chelate fragment as the result of the orientation in the same direction of the nitrogen atom of the oxime group and the hydroxy groups at C-3 and C-5.

Keywords

Oxime Cardenolides Lithium Hydroxide Oxime Group Aldoximes 

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Literature cited

  1. 1.
    I. F. Makarevich, in: Modern Problems of Pharmaceutical Science and Practice [in Russian], Kiev (1972), p. 508.Google Scholar
  2. 2.
    A. Vovinkel and J. Bartel, Chem. Ber.,107, 1221 (1974).CrossRefGoogle Scholar
  3. 3.
    E. Cohnen, GFR Patent Application No. 2,558,208 (1977).Google Scholar
  4. 4.
    G. Baumgarten, Die Herzwirksamen Glykoside, Leipzig (1963).Google Scholar
  5. 5.
    V. V. Zatula, N. P. Maksyutina, and D. G. Kolesnikov, Med. Promst., SSSR, No. 11, 21 (1963).Google Scholar
  6. 6.
    I. F. Makarevich, É. P. Kemertolidze, S. G. Kislichenko, V. V. Zatula, A. A. Reznichenko, D. G. Kolesnikov, and I. P. Kovalev, Cardenolides and Bufadienolides [in Russian], Tbilisi (1975).Google Scholar
  7. 7.
    J. Schmutz, Pharm. Acta Helv.,22, 373 (1947).PubMedGoogle Scholar
  8. 8.
    G. A. Langer, Circ. Res.,35, No. 3, 91 (1974, Suppl).PubMedGoogle Scholar
  9. 9.
    T. Akera and T. M. Brody, Pharmacol. Rev.,29, No. 3, 187 (1977).PubMedGoogle Scholar
  10. 10.
    N. O. Gorchakova, V. M. Grebennikov, L. I. Budrin, and I. S. Chekman, Farm, Zh. (Ukrainian), No. 6,43 (1980).Google Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • I. F. Makarevich
  • M. V. Mokrouz
  • L. Ya. Topchii
  • I. P. Kovalev
  • V. E. Sokolova
  • Yu. I. Gubin
  • N. P. Bublik
  • V. A. Polyakov

There are no affiliations available

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