Chemistry of Natural Compounds

, Volume 19, Issue 5, pp 569–572 | Cite as

Influence of transformed steroids on Na+,K+-dependent ATPase. II

  • A. V. Kamernitskii
  • I. G. Reshetova
  • N. M. Mirsalikhova


The relationship of the structures of a number of transformed steroids containing an open or closed 20-oxo-21a,17-tetrahydrofuran ring E and 23-oic acid derivatives with their Na+,K+-ATPase inhibiting activity has been studied. It has been found that steroids with branched side chains are more active than steroids with additional tetrahydropyran-4- and -2-one rings E. The most active in this series of 20-ketosteroids are those containing such polar groupings as diketone and epoxyethyl groupings. Steroids with a spirotetrahydrofuran ring at C(17) exhibit an activity greater than their pyranoside analogs.


Oxime Cardenolides Porcine Kidney Butenolide Tetrahydropyran 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    N. M. Mirsalikhova, N. Sh. Pal'yants, and N. K. Abubakirov, Khim. Prir. Soedin., 95 (1978).Google Scholar
  2. 2.
    H. I. Portius and K. Repke, “Effects of steroids of different types on transport ATPase,” in: Symposium über Biochemisce Aspekte der Steroidforschung, Akad. Verlag, Berlin (1969), p. 179.Google Scholar
  3. 3.
    R. Thomas, J. Boutagy, and A. Gebbart, J. Pharm. Sci.,63, No. 11, 1661 (1974).CrossRefGoogle Scholar
  4. 4.
    N. M. Mirsalikhova, F. T. Umarova, N. Sh. Pal'yants, and N. K. Abubakirov, Khim. Prir. Soedin., 188 (1976).Google Scholar
  5. 5.
    A. V. Kamernitskii, I. G. Reshetova, N. M. Mirsalikhova, and F. T. Umarova, Biokhimiya,47, No. 6, 957 (1982).Google Scholar
  6. 6.
    P. L. Jorgensen, Biochim. Biophys. Acta,356, 36 (1974).CrossRefGoogle Scholar
  7. 7.
    H. T. Panusz, G. Graczyk, D. Wilmanska, and J. Skarzynski, Anal. Biochem.,35, 494 (1970).CrossRefGoogle Scholar
  8. 8.
    E. F. Hartree, Anal. Biochem.,48, 422 (1972).CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • A. V. Kamernitskii
  • I. G. Reshetova
  • N. M. Mirsalikhova

There are no affiliations available

Personalised recommendations