Skip to main content
SpringerLink
Log in

Kinetics of the formation of pantolactone from pantothenates and its quantitative determination

  • Published:
Chemistry of Natural Compounds Aims and scope

Abstract

The conditions of hydrolysis and lactonization of the calcium and sodium salts of pantothenic and pantoic acids have been studied. The selected conditions of hydrolysis (t=80°C, CHCl=13%) led to a 100% yield of β-alanine and pantothenates after 60 min from the beginning of hydrolysis, while the formation of pantolactone was complete in 105 min for the calcium salt and in 75 min for the sodium salt. The hydrolysis and lactonization reactions have been performed under the conditions mentioned, and the GLC of the pantolactone formed has permitted the determination of various concentrations of calcium pantothenate. The results obtained from the GLC analysis of pantolactone indicate the possibility of a quantitative determination of salts of pantothenic and pantoic acids. The sensitivity of this method is 0.2–5 nmole.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature cited

  1. A. G. Moiseenok, Experimental Vitaminology (A Handbook) [in Russian], Minsk (1979), p. 267.

  2. P. Tarli et al., Farmaco, Ed. Prat.,25, 504 (1970).

    Google Scholar 

  3. P. Tarli et al., Anal. Biochem.,42, 8 (1971).

    Google Scholar 

  4. C. Hesse et al., Klin. Wschr.,50, 55 (1972).

    Google Scholar 

  5. E. Schulze et al., Z. Klin. Chem. Klin. Biochem.,12, 498 (1974).

    Google Scholar 

  6. E. Schulze, Zur Wiesch Entwicklung und Anwendung einer Gaschromatographischen Methoden Zur Bestimmung von Pantothensäure in Urin, Bonn (1974).

  7. E. Tesmer et al., Die Nahrung,24, No. 8, 697 (1980).

    Google Scholar 

  8. E. Tesmer and D. Hötzel, Anal. Chem.,227, 124 (1975).

    Google Scholar 

  9. V. M. Kopelevich, A. V. Lysenkova et al., Khim. Prir. Soedin., 482 (1981).

  10. C. K. Ingold, Structure and Mechanism in Organic Chemistry, 2nd edn., Cornell University Press, Ithaca, New York (1979).

    Google Scholar 

  11. N. M. Émanuél' and D. G. Knorre, A Course of Chemical Kinetics [in Russian], Moscow (1974), p. 166.

Download references

Authors
  1. A. G. Moiseenok
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. S. Slyshenkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. V. Lysenkova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Department of Metabolic Regulation, Academy of Sciences of the Belorussian SSR, Grodno. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 93–95, January–February, 1984.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moiseenok, A.G., Slyshenkov, V.S. & Lysenkova, A.V. Kinetics of the formation of pantolactone from pantothenates and its quantitative determination. Chem Nat Compd 20, 88–90 (1984). https://doi.org/10.1007/BF00574801

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00574801

Keywords

Search

Navigation