Chemistry of Natural Compounds

, Volume 17, Issue 6, pp 571–574 | Cite as

Microbiological synthesis of 7-bromo-5-(o-chlorophenyl)-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one by immobilized actinomycetes

  • T. I. Davidenko
  • N. N. Zabolotskaya


It has been shown that the highest yields (15%) of 7-bromo-5-(o-chlorophenyl)-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one are obtained by the use of the cells of actinomycetes immobilized in poly(vinyl alcohol) in the presence of the cosubstrate 7-bromo-5-(o-chlorophenyl)-3-methyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one.


Immobilize Cell Vinyl Alcohol Phenazepam Microbiological Synthesis Dibutyl Ester 


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Literature cited

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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • T. I. Davidenko
  • N. N. Zabolotskaya

There are no affiliations available

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