Advertisement

Acta Diabetologica

, Volume 29, Issue 3–4, pp 218–220 | Cite as

Prostaglandins and the kidney in diabetes

  • F. Pugliese
  • G. A. Cinotti
  • P. Menè
Invited Speakers
  • 45 Downloads

Abstract

The kidney is an active site of prostaglandin synthesis. These autacoids can influence renal haemodynamics, glomerular ultrafiltration coefficient, mesangial cell proliferation and matrix expansion. Due to these features, prostaglandins may contribute to virtually all the functional and structural alterations which characterize the different phases of diabetic nephropathy. Indeed, most of the experimental as well as clinical studies to date agree that renal hyperfiltration of early diabetes is partially dependent upon enhanced renal production of vasodilatory prostaglandins. By contrast, in long-term diabetes the reduced renal synthesis of prostaglandins and increased production of intrarenal thromboxane, be the latter derived from native glomerular cells or from infiltrating platelets or monocytes, would appear to contribute to the decline in glomerular filtration rate, glomerular basement membrane alterations and proteinuria.

Key words

Prostaglandins Thromboxane Diabetes Diabetic nephropathy Hyperfiltration Eicosanoids 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Van de Bosch H, Intracellular phospholipase A. Biochim Biophys Acta 604:191–246, 1980Google Scholar
  2. 2.
    Bell RL, Kennerly DA, Stanford N, Majerus PW, Diglyceride lipase: a pathway for arachidonate release from human platelets. Proc Natl Acad Sci USA 76:3238–3241, 1979Google Scholar
  3. 3.
    Burch RH, Axelrod J, Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2. Proc Natl Acad Sci USA 84:6374–6378, 1987Google Scholar
  4. 4.
    Ciabattoni G, Pugliese F, Studies of renal eicosanoids in vivo and in vitro. Adv Exp Med Bio 289:361–388, 1989Google Scholar
  5. 5.
    Pugliese F, Patrono C, Vasoactive hormones and autacoids regulating glomerular hemodynamics and mesangial cell proliferation. In: Gentilini P, Arias IM, Arroyo V, Schrier RW (eds) Liver disease and renal complications. Raven Press, New York, pp 300–307, 1990Google Scholar
  6. 6.
    Craven PA, Davidson CM, DeRubertis FR, Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids. Diabetes 39:667–674, 1990Google Scholar
  7. 7.
    Ayo SH, Radnik R, Garoni JA, Troyer DA, Kreisberg JI, High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures. Am J Physiol 261:F571-F578, 1991Google Scholar
  8. 8.
    Craven PA, DeRubertis FR, Protein kinase C is activated in glomeruli from streptozotocin diabetic rats: possible mediation by glucose. J Clin Invest 83:1667–1675, 1989Google Scholar
  9. 9.
    Pugliese F, Singh AK, Kasinath BS, Kreisberg JI, Lewis EJ, Glomerular epithelial cell polyanion neutralization is associated with enhanced prostanoid production. Kidney Int 32:57–61, 1987Google Scholar
  10. 10.
    Pugliese F, Menè P, Anania MC, Cinotti GA, Neutralization of the anionic sites of cultured mesangial cells by poly-L-lysine. Kidney Int 35:817–823, 1989Google Scholar
  11. 11.
    Moel DI, Safirstein RL, McEvoy RC, Hsueh W, Effect of aspirin on experimental diabetic nephropathy. J Lab Clin Med 110:300–307, 1987Google Scholar
  12. 12.
    Craven PA, DeRubertis FR, Role of local prostaglandin and thromboxane production in the regulation of glomerular filtration rate in the rat with streptozotocin-induced diabetes. J Lab Clin Med 113:674–681, 1989Google Scholar
  13. 13.
    Gambardella S, Andreani D, Cancelli A, Di Mario U, Cardamone I, Stirati G, Cinotti GA, Pugliese F, Renal hemodynamics and urinary excretion of 6-keto-prostaglandin F and thromboxane B2 in newly diagnosed type I diabetic patients. Diabetes 37:1044–1048, 1988Google Scholar
  14. 14.
    Esmajetes E, Fernandez MR, Halperin I, Camps J, Gaya J, Arroyo V, Rivera F, Figuerola D, Renal hemodynamic abnormalities in patients with short term insulin-dependent diabetes mellitus: role of renal prostaglandins. J Clin Endocrinol Metab 60:1231–1236, 1985Google Scholar
  15. 15.
    Craven PA, Patterson MC, DeRubertis FR, Role of enhanced arachidonate availability through the phospholipase A2 pathway in the mediation of increased prostaglandin synthesis by glomeruli from diabetic rats. Diabetes 37:429–435, 1988Google Scholar
  16. 16.
    Ciabattoni G, Cinotti GA, Pierucci A, Simonetti BM, Manzi M, Pugliese F, Barsotti P, Pecci G, Taggi F, Patrono C, Effects of sulindae and ibuprofen in patients with chronic glomerular disease. N Engl J Med 310:279–283, 1984Google Scholar
  17. 17.
    Hommel E, Mathiesen E, Arnold-Larsen S, Edsberg B, Olsen UB, Parving HH, Effects of indomethacin on kidney function in type I (insulin-dependent) diabetic patients with nephropathy. Diabetologia 30:78–81, 1987Google Scholar
  18. 18.
    Barnett AH, Leatherdale BA, Britton JR, Polak A, Bennett J, Toop M, Rowe D, Dallinger K, Specific thromboxane synthetase inhibition and albumin excretion rate in insulin-dependent diabetes, Lancet I:1322–1325, 1984Google Scholar
  19. 19.
    Donadio JV, Duane M, Ilsstrup MS, Holley KE, Romero JC, Platelet-inhibitor treatment of diabetic nephropathy: a 10-year prospective study. Mayo Clin Proc 63:3–15, 1988Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • F. Pugliese
    • 1
  • G. A. Cinotti
    • 1
  • P. Menè
    • 1
  1. 1.Cattedra di NefrologiaUniversity of Rome “La Sapienza”RomeItaly

Personalised recommendations