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Archives of Orthopaedic and Trauma Surgery

, Volume 115, Issue 2, pp 111–114 | Cite as

Healing of a tibial double osteotomy is modified by clodronate administration

An experimental study
  • M. T. Nyman
  • T. Gao
  • T. C. Lindholm
  • T. S. Lindholm
Clinical and Experimental Forum

Abstract

We studied the healing of tibial double osteotomies in rats during clodronate administration 10 mg/kg daily subcutaneously for 6 weeks. Clodronate treatment did not inhibit the endochondral bone formation in callus or in the epiphyseal plate. The differentiation of osteoblasts into mature osteocytes was disturbed, and the bone structure around the osteocytes was not normal. In the clodronatetreated group, the amount of newly formed bone matrix seemed increased, but mineralization of the bone matrix was delayed. The bundle bone trabeculae in callus were not so spatially well organized as in the controls. No delay in the union of the bone segment by new bone was seen during clodronate administration.

Keywords

Public Health Bone Formation Bone Trabecula Bone Matrix Bone Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bauer HCF, Törngvist H, Nilsson OS (1986) Effects of biphosphonates on the incorporation of calcium-45 and 3H-proline in orthopic and in demineralized matrix-induced bone in rats. Bone 7:129Google Scholar
  2. 2.
    Chappard D, Petitjean M, Alexandre C, Vico L, Minaire P, Riffat G (1991) Cortical osteoclasts are less sensitive to etidronate than trabecular osteoclasts. J Bone Joint Res 6:673Google Scholar
  3. 3.
    Flanagan AM, Chambers TJ (1989) Dichloromethylenebiphosphonate (Cl2MBP) inhibits bone resorption through injury to osteoclasts that resorb Cl2MBP-coated bone. Bone Miner 6:33Google Scholar
  4. 4.
    Fornasserier VL (1977) Osteoid: an ultrastructural study. Hum Pathol 8:243Google Scholar
  5. 5.
    Giannini S, D'Angelo A, Malvasi L, Castrignano R, Tronca R, Liberto L, Nobile M, Crepaldi G (1993) Effects of one-year cyclical treatment with clodronate on posttraumatic bone loss. Bone 14:137Google Scholar
  6. 6.
    Jung A, Bornand J, Mermillod B, Edouard C, Meunier PJ (1984) Inhibition by diphosphonates of bone resorption induced by the Walker tumor of the rat. Cancer Res 44:3307Google Scholar
  7. 7.
    Kanis JA, McCloskey EV, Sirtori P, Khan S, Fern D, Eyres K, Aaron J, Beneton MN (1993) Rationale for the use of clodronate in osteoporosis. Osteopor Int 3 (Suppl 2):23–28Google Scholar
  8. 8.
    Lepore L, Pennesi M, Barbi E, Pozzi R (1991) Treatment and prevention of osteoporosis in juvenile chronic arthritis with disodium clodronate. Clin Exp Rheumatol 9 (Suppl 6):33Google Scholar
  9. 9.
    Miller SC, Jee WSS (1979) The effect of dichloromethylene diphosphonate, a pyrophosphate analog, on bone and bone cell structure in the growing rat. Anat Rec 193:439Google Scholar
  10. 10.
    Nyman MT, Paavolainen P, Lindholm TS (1993) Clodronate increases the calcium content in fracture callus: an experimental study in rats. Arch Orthop Trauma Surg 112:228Google Scholar
  11. 11.
    Nyman MT, Paavolainen P, Holmströnm T, Penttinen R, Verkasalo M (1993) Clodronate reduces plate osteopenia in the rabbit. Acta Orthop Scand 64:50Google Scholar
  12. 12.
    Raina V (1972) Normal osteoid tissue. J Clin Pathol 25:229Google Scholar
  13. 13.
    Schenk R, Merz WA, Muhlbauer R, Russell RGG, Fleisch H (1973) Effect of ethane- 1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (CI2MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats. Calcif Tissue Res 11:190Google Scholar
  14. 14.
    Vaes G (1988) Cellular biology and biomechanical mechanism of bone resorption. A review of recent developments on the formation, activation and mode of action of osteoclasts. Clin Orthop 231:239Google Scholar
  15. 15.
    Vanderwiel CJ (1980) An ultrastructural study of the components which make up the resting surface of bone. Metab Bone Dis 2 (Suppl):109Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • M. T. Nyman
    • 1
    • 2
  • T. Gao
    • 1
  • T. C. Lindholm
    • 1
  • T. S. Lindholm
    • 1
    • 3
  1. 1.Medical SchoolUniversity of TampereFinland
  2. 2.Department of OrthopaedicsTampere University HospitalTampereFinland
  3. 3.Institute of DentistryTurku UniversityTurkuFinland

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