Archives of Orthopaedic and Trauma Surgery

, Volume 115, Issue 2, pp 111–114 | Cite as

Healing of a tibial double osteotomy is modified by clodronate administration

An experimental study
  • M. T. Nyman
  • T. Gao
  • T. C. Lindholm
  • T. S. Lindholm
Clinical and Experimental Forum


We studied the healing of tibial double osteotomies in rats during clodronate administration 10 mg/kg daily subcutaneously for 6 weeks. Clodronate treatment did not inhibit the endochondral bone formation in callus or in the epiphyseal plate. The differentiation of osteoblasts into mature osteocytes was disturbed, and the bone structure around the osteocytes was not normal. In the clodronatetreated group, the amount of newly formed bone matrix seemed increased, but mineralization of the bone matrix was delayed. The bundle bone trabeculae in callus were not so spatially well organized as in the controls. No delay in the union of the bone segment by new bone was seen during clodronate administration.


Public Health Bone Formation Bone Trabecula Bone Matrix Bone Structure 
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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • M. T. Nyman
    • 1
    • 2
  • T. Gao
    • 1
  • T. C. Lindholm
    • 1
  • T. S. Lindholm
    • 1
    • 3
  1. 1.Medical SchoolUniversity of TampereFinland
  2. 2.Department of OrthopaedicsTampere University HospitalTampereFinland
  3. 3.Institute of DentistryTurku UniversityTurkuFinland

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