Determination of thiodiglycolic acid in urine specimens of vinyl chloride exposed workers

  • G. Müller
  • K. Norpoth
  • E. Kusters
  • K. Herweg
  • E. Versin


A strong correlation was found between vinyl chloride concentrations at working places and the increased excretion of thiodiglycolic acid of 18 exposed workers. The mean air concentration of vinyl chloride was calculated referring to personal exposure. The values obtained were in the range of 0,14–7,0 ppm. The excretion of thiodiglycolic acid — measured by GC-MS analysis — amounted to 0,3 – 4,0 mg/L. It could be demonstrated that significant increases of the metabolite excretion occur even at VC-concentrations below 5 ppm.

Key words

Vinyl chloride Thiodiglycolic acid vinyl chloride metabolism in man Vinyl chloride urine metabolites Biological exposure control 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • G. Müller
    • 1
  • K. Norpoth
    • 1
  • E. Kusters
    • 2
  • K. Herweg
    • 3
  • E. Versin
    • 2
  1. 1.Institut für Staublungenforschung und Arbeitsmedizin der Westf. Wilhelms-UniversitätMünsterGermany
  2. 2.Werksärztliche Abteilung der BASFAntwerpenBelgien
  3. 3.Werksärztliche Abteilung der Chemischen Werke Hüls AGMarl-HülsGermany

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