Abstract
Heavy applications of suspensions of killedMalassezia ovalis on rabbit skin produced lesions that both grossly and microscopically resembled human psoriasis. This system may afford not only a model but also an explanation for that disease.
Similar content being viewed by others
References
1979. Research Needs in 11 Major areas in dermatology. I. Psoriasis. J. Invest. Derm. 73: 402–413.
Belew, P.W., E.W. Rosenberg, & B.R. Jennings. 1980. Activation of the alternative pathway of complement by Malassezia ovalis (Pityrosporum ovale). Mycopathologia. In press.
Benham, R.W. 1939. The cultural characteristics of Pityrosporum ovale — a lipophylic fungus. J. Invest. Derm. 2: 187–203.
Bizzozero, J. 1884. Über die mikrophyten der normalen oberhaut des menschen. Arch. f. Path. Anat. u. Physiol. u.f. Klin. Med. 98: 441–459.
Bjornson, A.B. & H.S. Bjornson. 1977. Activation of complement by opportunist pathogens and chemotypes of Salmonella minnesota. Inf. Immun. 16: 748–753.
Brauner, G.J. 1979. Seborrheic dermatitis, in Dermatogy in General Medicine. T.B., Fitzpatrick, A.Z., Eisen, K., Wolf, I.M., Freedberg & K.F. Austen. 2nd, McGraw-Hill, NewYork. 803.
Braun-Falco, O., G.P., Heilgemeir, & H. Lincke-Plewig. 1979. Histologische differentialdiagnose von psoriasis vulgaris and seborrhoischem ekzem des kapillitium. Der Hautarzt. 30: 478–483.
Castellani, A. & A.J. Chalmers. 1913. Manual of Tropical Medicine. 2nd ed, Bailliere, Tindall & Cox, London. 1–1747.
Civatte, A. 1924. Psoriasis and seborrheic eczema: Pathological anatomy and diagnostic histology of the two dermatoses. Brit. J. Derm. 36: 461–476.
Dahl, M.V., W.E. Lindroos & R.D. Nelson. 1978. Chemokinetic and chemotactic factors in psoriasis scale extracts. J. Invest. Derm. 71: 402–406.
Fergusson, A.G., N.G., Fraser & P.W. Grant. 1966. Napkin dermatitis with psoriasiform ‘IDE’. A review of 52 cases. Brit. J. Derm. 78: 289–296.
Fowlks, W.L., D.G., Griffith & E.L., Oginsky. 1958. Photosensitization of bacteria by furocoumarins and related compounds. Nat. 181: 571–572.
Kile, R.L. & M.F. Engman. 1938. Further studies of the relation of Pityrosporum ovale to seborrheic eczema. Arch. Derm. Syph. 37: 616–626.
Marples, R. 1975. Fundamental cutaneous microbiology, in Dermatology. S.L., Moschella, D.M., Pillsbury & H.J. Hurley. 1st. ed., W.B. Saunders, Philadelphia. 482.
Martin-Scott, J. 1952. The Pityrosporum ovale. Brit. J. Derm. 64: 257–273.
McGinley, K.J., J.J., Leyden, R.R., Marples & A.M. Kligman. 1975. Quantitative microbiology of the scalp in non-dandruff, dandruff, and seborrheic dermatitis, J. Invest. Derm. 64: 401–405.
Miescher, P.A. & H.J. Muller-Eberhard. 1976. Textbook of Immunopathology, 2nd ed, Grune and Stratton, New York, 45–73.
Moore, M. & R.L. Kile. 1935. Pityrosporum ovale as a causative agent of seborrheic dermatitis. Sci. 81: 277–278.
Moore, M., R.L. Kile, M.F. Engman, Jr. & M.F. Engman. 1936. Pityrosporum ovale (bottle baccilus of Unna, spore of Malassez) cultivation and possible role in seborrheic dermatitis. Arch. Derm. Syph. 33: 457–472.
Muftic, M. & G. Hoyer. 1968. Alkylamino alkyl-dithiocarbamic acids, new drugs against Pityrosporum ovale. Arzneim Forsch. 18: 1205–1207.
Noer, H.R. 1966. An experimental epidemic of Reiters' syndrome. J.A.M.A. 198: 693–698.
Ota, M., & P.T. Huang. 1933. Sur les champignons du genre Pityrosporum Sabouraud. Annal. d. Parasitol. 11: 49–69.
Pillemer, L., L., Blum, I.H. Lepow, O.A., Ross, E.W., Todd, & A.C. Wardlaw. 1954. The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena. Sci. 120: 279–285.
Pinkus, H. & A.H. Mehregan. 1966. The primary histologic lesion of seborrheic dermatitis and psoriasis. J. Invest. Derm. 46: 109–116.
Ray, T.L., A., Hanson, L.F., Ray & K.D. Wuepper. 1979. Purification of a mannan from Candida albicans which activates serum complement. J. Invest. Derm. 73: 269–274.
Ray, T.L. & K.D. Wuepper. 1976. Activation of the alternative (properdin) pathway of complement by Candida albicans and related species. J. Invest. Derm. 67: 700–703.
Ray, T.L. & K.D. Wuepper. 1978. Experimental cutaneous Candidiasis in rodents. Arch. Derm. 114: 539–543.
Rivolta, S. 1873. Parassiti Vegetali, 1st ed, di Giulio Speirani F. Figli, Torino, Italy, 469–471.
Sabouraud, R. 1904. Pityriasis et alopecies peliculaires; Les maladies desquamatives. 1st ed., Masson et cie, Paris, 295–374.
Sedwick, J.B., P.R., Bergstresser & E.R. Hurd. 1979. Increased PMN activation by serum from patients with psoriasis. J. Invest. Derm. 73: 312.
Sohnle, P.G. & C. Collins-Lech. 1978. Cell-mediated immunity to Pityrosporum orbiculare in tinea versicolor. J. Clin. Invest. 62: 45–53.
Sohnle, P.G., M.M., Frank, & C.H. Kirkpatrick. 1976. Mechanisms involved in elimination of organisms from experimental cutaneous Candida albicans infections in guinea pigs. J. Immunol. 117: 523–530.
Spoor, H.J., E.F. Traub & M. Bell. 1954. Pityrosporum ovale types cultured from normal and seborrheic subjects. Arch. Derm.Syph. 69: 323–330.
Tagami, H. & S. Ofuji. 1976. Leukotactic properties of soluble substances in psoriasis scale. Brit. J. Derm. 95: 1–7.
Tagami, H. & S. Ofuji. 1977. Demonstration of C3 cleavage product in leukotactic substances of scale extract from pustular psoriasis. Brit. J. Derm. 96: 94–95.
Tauber, J.W., M.J., Polley & J.B. Zabriskie. 1976. Nonspecific complement activation by Streptococcal structures. II. Properdin — independent initiation of the alternate pathway. J. Exp. Med. 143: 1352–1366.
Wallace, M., H., Bagnall, D., Glen & S. Averill. 1979. Isolation of lipophilic yeast in ‘sterile’ peritonitis. Lanc. 2(2) 956.
Whyte, HJ., & R.D. Baughman. 1964. Acute guttate psoriasis and Streptococcal infection. Arch. Derm. 89: 350–356.
Zaias, N. & H. Baden. 1979. Nails, in Dermatology in General Medicine, T.B., Fitzpatrick, A.Z., Eisen, K., Wolf, I.M., Freedberg, & K.F. Austen. 2nd ed, McGraw-Hill, New York. 424–427.
Author information
Authors and Affiliations
Additional information
Supported in part by grants from The Dermatology Foundation and The E. E. Muirhead Associates Fund.
Rights and permissions
About this article
Cite this article
Rosenberg, E.W., Belew, P. & Bale, G. Effect of topical applications of heavy suspensions of killed Malassezia ovalis on rabbit skin. Mycopathologia 72, 147–154 (1980). https://doi.org/10.1007/BF00572657
Issue Date:
DOI: https://doi.org/10.1007/BF00572657