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Acta Diabetologica

, Volume 29, Issue 2, pp 113–114 | Cite as

Internalization of glimepiride and glibenclamide in the pancreatic B-cell

  • G. Marynissen
  • G. Smets
  • G. Klöppel
  • L. Gerlache
  • W. J. Malaisse
Short Communication

Abstract

When rat pancreatic islets were exposed for 30 min at 37°C to tritiated glibenclamide (2.5 μM) or glimepiride (1.5 μM), internalization of these hypoglycaemic sulphonylureas in B and non-B cells was observed by autoradiography. In the B cell, the autoradiographic grains were often associated with secretory granules.

Key words

Glimepiride Glibenclamide Pancreatic islets 

References

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • G. Marynissen
    • 1
  • G. Smets
    • 2
  • G. Klöppel
    • 2
  • L. Gerlache
    • 3
  • W. J. Malaisse
    • 1
  1. 1.Laboratory of Experimental MedicineBrussels Free UniversityBrusselsBelgium
  2. 2.Department of Experimental PathologyBrussels Free UniversityBrusselsBelgium
  3. 3.Faculty of AgronomyUCLLouvain-la-NeuveBelgium

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