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Vascular changes of chronic lupus erythematosus

Electron microscopic studies

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Summary

Vascular changes in the course of chronic lupus erythematosus were mainly characterized by a large, yet varying degree of proliferation of endothelial cells. In all cases examined the presence of tubular forms similar to paramyxoviruses was noted.

The vascular basal membrane was noted to be either widened, segmentally separated or absent in places. Collagen fibres in these cases adhered directly to the endothelial cells.

In the nuclei of endothelial cells of the infiltrate, “nuclear bodies” could be observed. In area surrounding capillaries oval concentrations of fibrilles 80 Å in diameter were noticed.

Zusammenfassung

Die wesentliche Proliferation des Endothels von verschiedener Intensität ist beim chronischen Lupus erythematodes für die beobachteten Gefäßveränderungen bezeichnend.

In allen untersuchten Fällen wurden die paramyxovirusähnlichen tubulären Strukturen aufgewiesen. Die Basalmembran unterlag Veränderungen in Form teilweiser Erweiterung und Zerspaltung oder herdartiger Atrophie. In diesen Fällen liegen die kollagen Fasern unmittelbar an den Endothelien.

In den Kernen des Endothels und den Zellinfiltrationen traten oft “nuclear bodies” auf. In der Umgebung der Capillaren war das Vorhandensein scharf begrenzter, ovaler Fibrillenanhäufungen mit ca. 80 Å Durchmesser bemerkbar.

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Authors and Affiliations

  1. Dermatology Clinic, Laboratory of Electron Microscopy, Medical School, Zwyciestwa 42a, 80-210, Gdansk, Poland

    J. Kozakiewicz & Teresa Wrzołkowa

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  1. J. Kozakiewicz
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  2. Teresa Wrzołkowa
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Kozakiewicz, J., Wrzołkowa, T. Vascular changes of chronic lupus erythematosus. Arch. Derm. Res. 256, 327–331 (1976). https://doi.org/10.1007/BF00572499

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