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The effect of X-ray irradiation upon the epithelial melanin unit of the hair bulb in hooded rat

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Summary

A marked increase in the quantity of pigment in the upper bulb, penetration of melanosomes into the papillae and vacuolisation of the bulb keratinocytes occurred as early as 4–6 h after irradiation with a dose 600–1200 R. Afterwards considerable hyperpigmentations appeared in the proximal segments of dystrophic and catagen hairs and melanin was found in the catagen columns and beyond them.

In most animals within 4–6 h after irradiation occurred a distinct vacuolisation of the Malpighian layer and the granular layer became more prominent.

Zusammenfassung

Nach einer Röntgenbestrahlung mit 600–1200 R trat schon nach 4–6 h Hyperpigmentierung des oberen Bulbus und Eindringen der Melanosomen in die Papille sowie die Vakuolisation der Bulbuskeratinocyten auf. Später entwickelten sich ausgesprochene Hyperpigmentierungen der proximalen Segmente der dystrophischen Haare und Melanin wurde in den Haarwurzelscheiden, innerhalb und außerhalb der Katagensäulen gefunden.

Die Mehrzahl der Tiere zeigte schon 4–6 h nach der Bestrahlung eine Vakuolisation des lebenden Epidermis; die granuläre Schicht trat deutlicher hervor.

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This work has been performed under the auspices of U.S. Environmental Protection Agency, Research Contract No 5–536–3.

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Kostanecki, W., Radwan, I. & Mroczkowski, T. The effect of X-ray irradiation upon the epithelial melanin unit of the hair bulb in hooded rat. Arch. Derm. Res. 256, 297–303 (1976). https://doi.org/10.1007/BF00572496

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  • DOI: https://doi.org/10.1007/BF00572496

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