Archives of Dermatological Research

, Volume 256, Issue 3, pp 265–273 | Cite as

Metabolism of testosterone 4-14C in skin of castrated rats

  • E. Rampini
  • P. Cardo
  • Carla Cipriani
  • G. Moretti


Testosterone metabolism was studied in the skin and preputial glands of normal and prepuberally castrated male rats during the 2nd hair cycle. In catagen-telogen the 17-beta-OHSDH of dorsal skin was higher in castrated than in control animals; 5-alpha-reductase instead, remained unchanged through out the hair cycle.

Also in the preputial glands of castrated rats 17-beta-OHSDH was higher than in normal rats. So was 5-alpha-reductase. A possible direct control of a substrate, like Testosterone, and/or of a hypophyseal tropin, like prolactin, on enzymes that direct the metabolism of steroids in target tissues is conceivable.


Public Health Enzyme Steroid Testosterone Prolactin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Die Autoren studierten den Testosteron-Metabolismus der Haut und der Präputialdrüsen von normalen männlichen Ratten, die in der Vorpubertät während des zweiten Haarzyklus kastriert wurden.

Im Katagen- und im Telogen-Stadium war die 17-beta-Hydroxysteroid-Dehydrogenase der Rückhaut in den kastrierten Ratten höher als in den normalen Ratten; dagegen blieb die 5-alpha-Reductase während des ganzen Haarzyklus unverändert.

Auch in den Präputialdrüsen der kastrierten Ratten waren die 17-beta-Hydroxysteroid-Dehydrogenase und die 5-alpha-Reductase höher als in den normalen Ratten.

Man darf annehmen, daß eine direkte Kontrolle eines Substrates — Testosteron und/oder eines pituitären Tropin als Prolactin — über Enzyme, die für den Metabolismus der Steroide im “Target”-Zielgewebe verantwortlich sind, denkbar ist.


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • E. Rampini
    • 1
  • P. Cardo
    • 1
  • Carla Cipriani
    • 1
  • G. Moretti
    • 1
  1. 1.Department of DermatologyUniversity of GenoaGenoaItaly

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