Archives of Dermatological Research

, Volume 256, Issue 3, pp 265–273 | Cite as

Metabolism of testosterone 4-14C in skin of castrated rats

  • E. Rampini
  • P. Cardo
  • Carla Cipriani
  • G. Moretti
Article

Summary

Testosterone metabolism was studied in the skin and preputial glands of normal and prepuberally castrated male rats during the 2nd hair cycle. In catagen-telogen the 17-beta-OHSDH of dorsal skin was higher in castrated than in control animals; 5-alpha-reductase instead, remained unchanged through out the hair cycle.

Also in the preputial glands of castrated rats 17-beta-OHSDH was higher than in normal rats. So was 5-alpha-reductase. A possible direct control of a substrate, like Testosterone, and/or of a hypophyseal tropin, like prolactin, on enzymes that direct the metabolism of steroids in target tissues is conceivable.

Keywords

Public Health Enzyme Steroid Testosterone Prolactin 

Zusammenfassung

Die Autoren studierten den Testosteron-Metabolismus der Haut und der Präputialdrüsen von normalen männlichen Ratten, die in der Vorpubertät während des zweiten Haarzyklus kastriert wurden.

Im Katagen- und im Telogen-Stadium war die 17-beta-Hydroxysteroid-Dehydrogenase der Rückhaut in den kastrierten Ratten höher als in den normalen Ratten; dagegen blieb die 5-alpha-Reductase während des ganzen Haarzyklus unverändert.

Auch in den Präputialdrüsen der kastrierten Ratten waren die 17-beta-Hydroxysteroid-Dehydrogenase und die 5-alpha-Reductase höher als in den normalen Ratten.

Man darf annehmen, daß eine direkte Kontrolle eines Substrates — Testosteron und/oder eines pituitären Tropin als Prolactin — über Enzyme, die für den Metabolismus der Steroide im “Target”-Zielgewebe verantwortlich sind, denkbar ist.

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • E. Rampini
    • 1
  • P. Cardo
    • 1
  • Carla Cipriani
    • 1
  • G. Moretti
    • 1
  1. 1.Department of DermatologyUniversity of GenoaGenoaItaly

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