, Volume 21, Issue 2, pp 174–186 | Cite as

Effects of LSD on time-based schedules of reinforcement

  • James B. Appel
Original Investigations Animal Studies


The functional relationship between rate of bar-pressing and a wide range of dosages of LSD was studied under different conditions or schedules of reinforcement, i.e., variable-interval (VI), differential reinforcement of low rate (drl), and drl plus concurrent periods of punishment. In general, low doses (0.01–0.04 nig/kg of LSD) increased or facilitated responding as an inverse function of base line response rate and high doses (0.08–0.32 mg/kg) depressed behavior not already depressed by environmental contingencies.


Lysergic Acid Diethylamide (LSD) Variable Interval (VI) Timing Behavior Punishment Rats 


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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • James B. Appel
    • 1
  1. 1.Department of PsychiatryThe University of ChicagoUSA

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