, Volume 21, Issue 2, pp 165–173 | Cite as

The effects of acutely administered fenfluramine on activity and eating behaviour

  • M. Taylor
  • J. Livesey
  • T. Dempster
  • R. Bunce
Original Investigations Animal Studies


Three experiments are reported investigating the effects of acute administration of fenfluramine over 3 doses on activity, eating and drinking behaviour. A time sampling procedure of activity analysis was used, employing six behaviour categories. Fenfluramine produced a dose related decrease in rearing behaviours, with some evidence of an increase in walking categories at the lower dose levels. Eating and drinking behaviours showed clear dose related decreases. Sniffing categories showed a clear dose related increase. Attention is drawn to some of the difficulties of interpretation and assessment of anorexic effect.


Anorexic Effect Fenfluramine Activity Analysis Time Sampling Technique Rat 


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  1. Bindra, D., Blond, J.: A time sampling method for measuring general activity and its components. Canad. J. Psychol.12, 74–76 (1958).Google Scholar
  2. —, Spinner, N.: Response to different degrees of novelty: the incidence of various activities. J. exp. Anal. Behav.1, 340–350 (1958).Google Scholar
  3. Cole, S. O.: Interaction of amphetamine with conditions of food deprivation. Psychol. Rep.13, 387–390 (1963).Google Scholar
  4. —: Further study of the interactive effects of amphetamine and food deprivation. Psychol. Rep.16, 625–630 (1965).Google Scholar
  5. Draper, W. A.: A behavioural study of the home cage activity of the white rat. Behaviour28, 280–306 (1963).Google Scholar
  6. Duncan, L. J. P., Munro, J. F.: Current therapeutics. CCXLI —The present status of anorexic drugs. Practioner200, 167–173 (1968).Google Scholar
  7. Epstein, A. N.: Suppression of eating and drinking by amphetamine and other drugs in normal and hyperphagic rats. J. comp. physiol. Psychol.52, 37–45 (1959).Google Scholar
  8. Garg, M.: The effects of some central nervous system stimulant and depressant drugs on rearing activity in rats. Psychopharmacologia (Berl.)14, 150–156 (1969).Google Scholar
  9. Holland, H. C., Gupta, B. D.: Some correlated measures of activity and reactivity in two strains of rats selectively bred for differences in the acquisition of a conditioned avoidance response. Anim. Behav.14, 574–580 (1966).Google Scholar
  10. Leonard, C. A., Heil, G. C., Fellows, E. G.: Effects of anorectics in rats during chronic administration. Fed. Proc.25, 385 (1966).Google Scholar
  11. Morrison, C. F., Lee, P. N.: A comparison of the effects of nicotine and physostigmine on a measure of activity in the rat. Psychopharmacologia (Berl.)13, 210–221 (1968).Google Scholar
  12. Quinton, R. M., Halliwell, G.: Effects of methyl DOPA and DOPA on the amphetamine excitatory response in reserpinized rats. Nature (Lond.)200, 178–179 (1963).Google Scholar
  13. Rossum, J. van, Simons, F.: Locomotor activity and anorexic action. Psychopharmacologia (Berl.)14, 248–254 (1969).Google Scholar
  14. Thompson, T., Schuster, C. R.: Behavioural pharmacology. New Jersey: Prentice Hall 1968.Google Scholar
  15. Winocur, G., Bagchi, S. P., Young, J. D.: Behavioral change in rats following bufotenine injection. Percept. and Motor Skills28, 527–533 (1969).Google Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • M. Taylor
    • 1
    • 2
  • J. Livesey
    • 1
  • T. Dempster
    • 1
  • R. Bunce
    • 1
  1. 1.Department of PsychologyUniversity of LiverpoolLiverpool
  2. 2.Department of PsychologyUniversity College of North WalesBangorGreat Britain

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