Abstract
A fully automated program developed by us for measurement of left ventricular ejection fraction from equilibrium gated blood pool studies was evaluated in 130 additional patients. Both 6-min (130 studies) and 2-min (142 studies in 31 patients) gated blood pool studies were acquired and processed. The program successfully generated ejection fractions in 86% of the studies. These automatically generated ejection fractions were compared with ejection fractions derived from manually drawn regions of interest. When studies were acquired for 6-min with the patient at rest, the correlation between automated and manual ejection fractions was 0.92. When studies were acquired for 2-min, both at rest and during bicycle exercise, the correlation was 0.81. In 25 studies from patients who also underwent contrast ventriculography, the program suceessfully generated regions of interest in 22 (88%). The correlation between the ejection fraction determined by contrast ventribulography and the automatically generated radionuclide ejection fraction was 0.79.
References
Bacharach SL, Green MV, Schrepers CW (1981) Theoretical behavior of fixed and varying ROI methods for calculating EF. J Nucl Med 22:60
Borer JS, Bacharach SL, Green MV, Kent KM, Epstein SE, Johnston GE (1977) Real time radionuclide cineangiography in the noninvasive evaluation of global and regional left ventricular function at rest and during exercise in patients with coronary artery disease. N Engl J Med 296:839–844
Bourguignon MH, Douglass KH, Links JM, Wagner HN Jr (1981) Fully automated data acquisition, processing and display in equilibrium radioventriculography. Eur J Nucl Med 6:343–347
Burow RD, Strauss MW, Singleton R (1977) Analysis of left ventricular function from multiple gated acquisition cardiac blood pool imaging. Circulation 56:1024–1028
Douglas MA, Green MV (1978) A system for computer generation of left ventricular masks for use in computed ECG-gated radionuclide angiocardiography. In: Nuclear Cardiology: Selected Computer Aspects. JA Sorenson (ed). Society of Nuclear Medicine, New York, p 119
Goris ML, McKillop JH, Briandet PA (1981) A fully automated determination of the left ventricular region of interest in nuclear angiocardiography. Cardiovasc Radiol 4:117–123
Links JM, Douglass KH, Wagner HN Jr (1980) Patterns of ventricular emptying by Fourier analysis of gated blood pool studies. J Nucl Med 21:978–982
Okada RD, Kirshenbaum MD, Kushner FG (1980) Observer variance in the qualitative evaluation of left ventricular wall motion and the quantitation of left ventricular ejection fraction using rest and exercise multigated blood pool imaging. Circulation 61:128–136
Smith TD, Richards P (1976) A simple kit for the preparation of99mTc-labeled red blood cells. J Nucl Med 17:126–132
Sorensen SG, Caldwell J, Ritchie J, Hamilton G (1981) “Abnormal” responses of ejection fraction to exercise, in healthy subjects, caused by region-of-interest selection. J Nucl Med 22:1–7
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This work was supported in part by USPHS Grant GM 10548
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Douglass, K.H., Tibbits, P., Kasecamp, W. et al. Performance of a fully automated program for measurement of left ventricular ejection fraction. Eur J Nucl Med 7, 564–566 (1982). https://doi.org/10.1007/BF00571652
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DOI: https://doi.org/10.1007/BF00571652