Archives of Orthopaedic and Trauma Surgery

, Volume 111, Issue 5, pp 265–267 | Cite as

Types I and III procollagen extension peptides in serum respond to fracture in humans

  • S. Joerring
  • L. T. Jensen
  • G. R. Andersen
  • Julia S. Johansen
Clinical and Experimental Forum


Markers of types I and III collagen turnover were measured in serial blood samples in 16 patients with a Colles' fracture. The collagen markers were the carboxy-terminal extension peptide of type I procollagen (PICP) and the amino-terminal extension peptide of type III procollagen (PIIINP). Significant increases were found of PIIINP within 1 week and of PICP within 2 weeks. This sequential appearance of PIIINP and PICP was found to be in agreement with the appearance of types III and I collagen during early fracture healing as demonstrated in previous animal experimental studies. PICP had levelled off after 9 months, whereas PIIINP remained elevated. Osteocalcin, a serum marker of osteoblast activity, increased within 1 week and levelled off after 9 months. Correlations betwen the change in osteocalcin and those in PICP and PIIINP, respectively, were weak. These new biochemical markers may prove relevant as non-invasive markers of normal and pathological fracture healing in humans.


Osteocalcin Serial Blood Biochemical Marker Fracture Healing Pathological Fracture 
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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • S. Joerring
    • 1
  • L. T. Jensen
    • 2
  • G. R. Andersen
    • 1
  • Julia S. Johansen
    • 3
  1. 1.Department of Orthopedics AFrederiksberg HospitalDenmark
  2. 2.Department of RheumatologyHvidovre HospitalDenmark
  3. 3.Department of Clinical ChemistryGlostrup HospitalDenmark

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