Acta Neuropathologica

, Volume 89, Issue 6, pp 537–543 | Cite as

Axonal injury: a universal consequence of fatal closed head injury?

  • S. M. Gentleman
  • G. W. Roberts
  • T. A. Gennarelli
  • W. L. Maxwell
  • J. H. Adams
  • S. Kerr
  • D. I. Graham
Regular Paper


β-Amyloid precursor protein immunostaining has recently been shown to be a reliable method for detecting the damage to axons associated with fatal head injury. In an attempt to compare the efficacy of this technique with conventional histological detection of axonal damage, we have reanalysed sections from a large well-characterised series of head-injured and control patients. The results indicate that the frequency of axonal injury has been vastly underestimated using conventional silver techniques, and that axonal injury may in fact be an almost universal consequence of fatal head injury.

Key words

β-Amyloid precursor protein Head injury Diffuse axonal injury Immunocytochemistry Diagnosis 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • S. M. Gentleman
    • 1
    • 2
  • G. W. Roberts
    • 3
  • T. A. Gennarelli
    • 4
  • W. L. Maxwell
    • 5
  • J. H. Adams
    • 6
  • S. Kerr
    • 6
  • D. I. Graham
    • 6
  1. 1.Department of PsychiatryCharing Cross and Westminster Medical SchoolLondonUK
  2. 2.Department of AnatomyCharing Cross and Westminster Medical SchoolLondonUK
  3. 3.Division of Molecular NeuropathologySmith Beecham PharmaceuticalsHarlowUK
  4. 4.Division of NeurosurgeryHospital of University of PennsylvaniaPhiladelphiaUSA
  5. 5.Department of AnatomyUniversity of GlasgowGlasgowUK
  6. 6.University Department of Neuropathology Institute of Neurological SciencesSouthern General HospitalGlasgowUK

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