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Circadian rhythm of lithium toxicity in mice

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Abstract

The existence of cyclical (circadian) variations in lithium toxicity in mice was determined. Mice, standardized to a light-dark cycle, were injected with lithium chloride (940 mg/kg) at one of six times (20:00, 24:00, 4:00, 8:00, 12:00, and 16:00) and subsequently observed for mortality over 28 h. A significant (P<0.01) time-of-day effect was found for lithium-induced lethality, with highest lethality following injection at 12:00.

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Authors and Affiliations

  1. Group in Physiology and Pharmacology, University of California at San Diego, San Diego, California, USA

    Richard Hawkins, Daniel F. Kripke & David S. Janowsky

  2. Department of Psychiatry, University of California at San Diego, San Diego, California, USA

    Richard Hawkins, Daniel F. Kripke & David S. Janowsky

  3. Veterans Administration Hospital, San Diego, California, USA

    Richard Hawkins, Daniel F. Kripke & David S. Janowsky

Authors
  1. Richard Hawkins
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  2. Daniel F. Kripke
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  3. David S. Janowsky
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Hawkins, R., Kripke, D.F. & Janowsky, D.S. Circadian rhythm of lithium toxicity in mice. Psychopharmacology 56, 113–114 (1978). https://doi.org/10.1007/BF00571418

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  • DOI: https://doi.org/10.1007/BF00571418

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