Abstract
Separate groups of rats were given either 1 or 2 mg/kg injections of amphetamine 30 min before or after eating a preferred high-fat food. When given before eating as an anorexic treatment, amphetamine initially suppressed intake almost completely, but with repeated injections tolerance developed. In contrast, amphetamine given after eating as an aversion treatment initially had little effect on intake, but with repeated injections it suppressed intake almost completely in rats receiving the higher dose.
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References
Cappell, H., LeBlanc, A. E.: Conditioned aversion to saccharin by a single administration of Mescaline andd-amphetamine. Psychopharmacologia (Berl.)22, 352–356 (1971)
Cappell, H., LeBlanc, A. E.: Conditioned aversion by amphetamine: rates of acquisition and loss of the attenuating effects of prior exposure. Psychopharmacologia (Berl.)43, 157–162 (1975)
Carey, R. J.: Long-term aversion to a saccharin solution induced by repeated amphetamine injections. Pharmacol. Biochem. Behav.1, 265–270 (1973)
Corbit, J. D., Stellar, E.: Palatability, food intake, and obesity in normal and hyperhagic rats. J. Comp. Physiol. Psychol.58, 63–67 (1964)
Garcia, J., Hawkins, W. G., Rusinak, K. W.: Behavioral regulation of the milieu interne in man and rat. Science185, 824–830 (1974)
Harris, S. C., Ivy, A. C., Searle, L. M.: The mechanism of amphetamine induced loss of weight. JAMA134, 1468–1472 (1947)
LeMagnen, J.: Peripheral and systemic actions of food in the caloric regulation of intake. Ann. N. Y. Acad. Sci.157, 1126–1157 (1969)
Lyon, M., Robbins, T.: The action of central nervous system stimulant drugs: a general theory concerning amphetamine effects. Curr. Dev. Psychopharmacol.2, 130–131 (1975)
Martin, J. C., Ellinwood, E. H.: Conditioned aversion to a preferred solution following methamphetamine injections. Psychopharmacologia (Berl.)29, 253–261 (1973)
Pickens, R., Harris, W. C.: Self-administration ofd-amphetamine by rats. Psychopharmacologia (Berl.)12, 158–163 (1968)
Rozin, P., Kalat, J. W.: Specific hungers and poisoning as adaptive specializations of learning. Psychol. Rev.78, 459–486 (1971)
Schuster, C. R., Dockens, W. S., Woods, J. H.: Behavioral variables affecting the development of amphetamine tolerance. Psychopharmacologia (Berl.)9, 170–182 (1966)
Siegel, S.: Morphine tolerance acquisition as an associative process. J. Exp. Psychol. [Anim. Behav.]3, 1–13 (1977)
Winer, B. J.: Statistical principles in experimental design. New York: McGraw-Hill 1962
Yehuda, A.: Interaction effects ofd-amphetamine and ambient temperature on rats' food intake. Psychopharmacologia (Berl.)45, 229–232 (1976)
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Carey, R.J. A comparison of the food intake suppression produced by giving amphetamine as an aversion treatment versus as an anorexic treatment. Psychopharmacology 56, 45–48 (1978). https://doi.org/10.1007/BF00571407
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DOI: https://doi.org/10.1007/BF00571407