Abstract
A symmetrical cross-tolerance was found between two phencyclidine derivatives-phencyclidine and cyclohexamine-and also between two cholinergic drugs-physostigmine and oxotremorine. On the other hand, mice rendered tolerant to the phencyclidine derivatives showed cross-tolerance to these cholinergic drugs, but no cross-tolerance was observed in the opposite direction.
The applicability of such experiments to the elucidation of neurochemical interactions of centrally acting drugs is discussed.
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Pinchasi, I., Maayani, S., Egozi, Y. et al. On the interaction of drugs with the cholinergic nervous system. Psychopharmacology 56, 37–40 (1978). https://doi.org/10.1007/BF00571405
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DOI: https://doi.org/10.1007/BF00571405