, Volume 56, Issue 1, pp 1–4 | Cite as

Cholinergic inhibition of methylphenidate-induced stereotypy: Oxotremorine

  • Kenneth L. Davis
  • Leo E. Hollister
  • Jonathan Tepper


Lethality of orally administered oxotremorine for female mice required 250 times the dose that was effective for inhibiting methylphenidate-induced stereotypy. A number of lines of evidence indicate that increasing central cholinergic activity may be useful in various psychiatric syndromes and movement disorders. A relatively safe oral cholinomimetic would be clinically useful. Oxotremorine may be such an agent.

Key words

Dopamine Oxotremorine Methylphenidate-induced stereotypy 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Kenneth L. Davis
    • 1
  • Leo E. Hollister
    • 1
  • Jonathan Tepper
    • 1
  1. 1.Veterans Administration Hospital and Department of PsychiatryStanford University of MedicinePalo AltoUSA

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