References
Fleisch H (1988) Bisphosphonates: a new class of drugs in diseases of bone and calcium metabolism. In: Handbook of experimental pharmacology, vol 83. Springer-Verlag, Berlin, Heidelberg, pp 441–466
Kanis JA (1991) A new approach to the management of osteolytic bone metastases. Bone 12(suppl 1):S1–S45
Boonekamp PM, Van der Wee-Pals LJA, Van Wijk-van Lennep MML, Thesing CW, Bijvoet OLM (1986) Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix. Bone Miner 1:27–39
Flanagan AM, Chambers TJ (1989) Dichloromethylenebisphosphonate (Cl2MBP) inhibits bone resorption through injury to osteoclasts that resorb Cl2MBP-coated bone. Bone Miner 6:33–43
Van Rooijen N (1989) The liposome-mediated macrophage ‘suicide’ technique. Minireview. J Immunol Meth 124:1–6
Van Rooijen N, Van Nieuwmegen R, Kamperdijk EWA (1985) Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. Ultrastructural aspects of elimination of marginal zone macrophages. Virchows Arch B 49:375–383
Van Rooijen N (1991) High and low cytosolic Ca2+-induced macrophage death? Cell Calcium 12:381–384
Van Rooijen N, Poppema A (in press) Efficacy of various water-soluble chelator molecules in the liposome-mediated macrophage “suicide” technique. J Pharmacol Methods
Sillen LG, Martell AE (1964) Stability constants of metal-ion complexes. Special publication no. 17, Chemical Society of London
Sillen LG, Martell AE (1969) Stability constants of metal-ion complexes (suppl 1). Special publication no. 25, Chemical Society of London
Smith RM, Martell AE (1989) Critical stability constants. Plenum Press, New York
Graf E, Mahoney JR, Bryant RG, Eaton JW (1984) Iron-catalyzed hydroxyl radical formation. J Biol Chem 259:3620–3624
Mönkkönen J, Urtti A, Paronen P, Elo HA, Ylitalo P (1989) The uptake of clodronate (dichloromethylene bisphosphonate) by macrophages in vivo and in vitro. Drug Metab Dispos 17:690–693
Fleisch H (1983) Bisphosphonates. mechanism of action and clinical application. In: Peck WA (ed) Bone and mineral research annual 1. Excerpta Medica, Amsterdam, pp 319–357
Van Rooijen N, Kors N (1989) Effects of intracellular diphosphonates on cells of the mononuclear phagocyte system. In vivo effects of liposome encapsulated diphosphonates on different macrophage subpopulations in the spleen. Calcif Tissue Int 45: 153–156
Mönkkönen J, Van Rooijen N, Ylitalo P (1991) Effects of clodronate and pamidronate on splenic and hepatic phagocytic cells of mice. Pharmacol Toxicol 68:284–286
Rowe DJ, Hausmann E (1976) The alteration of osteoclast morphology by diphosphonates in bone organ culture. Calcif Tissue Int 20:53–60
Mönkkönen J, Ylitalo P, Elo HA, Airaksinen MM (1987) Distribution of 14C-clodronate (dichloromethylene bisphosphonate) disodium in mice. Tox Appl Pharmacol 89:287–292
Fontecave M, Pierre JL (1991) Minireview. Iron metabolism: the low-molecular mass iron pool. Biol Metals 4:133–135
Meunier PL, Alexandre C, Edouard C, Mathieu L, Chapuy MC, Bressot C, Vignon E, Trechsel U (1979) Effects of disodium dichloromethylene diphosphonate on Paget's disease of bone. Lancet ii:489–492
Klein G, Martin JB, Satre M (1988) Methylenedisphosphonate, a metabolic poison inDictyostelium discoideum. 31P NMR evidence for accumulation of adenosine (5′-(β,γ-methylenetriphosphate) and diadenosine 5′,5‴-P1,P4-(P2,P3-methylenetetraphosphate). Biochemistry 27:1897–1901
Saito T, Yamaguchi J (1985) 2-Chloroadenosine: a selective lethal effect to mouse macrophages and its mechanism. J Immunol 134:1815–1822
Kanis JA (1987) Clodronate, a new perspective in the treatment of neoplastic bone disease. Bone 8(suppl 1):S1–S90
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van Rooijen, N. Extracellular and intracellular action of clodronate in osteolytic bone diseases? A hypothesis. Calcif Tissue Int 52, 407–410 (1993). https://doi.org/10.1007/BF00571326
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DOI: https://doi.org/10.1007/BF00571326