Advertisement

Chemistry of Natural Compounds

, Volume 4, Issue 4, pp 199–201 | Cite as

Kinetics of the acid hydrolysis of uridine diphosphate glucose and 3-N-methyluridine diphosphate glucose

  • E. I. Budovskii
  • V. N. Shibaev
Article

Conclusions

  1. 1.
    The rate of acid hydrolysis of uridine diphosphate glucose as functions of the pH and the temperature is expressed by the equation
    $$\log {\text{k}}(\min ^{ - 1} ) = 25.45 - {\text{pH}} - \frac{{8300}}{{\text{T}}}.$$
     
  2. 2.

    The expression for the rate constant as functions of the pH and the temperature that has been obtained is in harmony with the idea that the acid hydrolysis of uridine diphosphate glucose takes place as a monomolecular substitution in its monoanion.

     
  3. 3.

    The replacement of the uridine residue by a 3-N-methyluridine residue in the molecule of a nucleoside diphosphate sugar does not lead to an appreciable change in the rate of acid hydrolysis.

     

Keywords

Acid Hydrolysis Diphosphate Uridine Sodium Carbonate Hydrogen Phthalate 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    N. K. Kochetkov, E. I. Budovskii, and V. N. Shibaev, Usp. biol. kh.,6, 108, 1964.Google Scholar
  2. 2.
    W. Kelleher, J. Pharm. Sci.,54, 1081, 1965.CrossRefGoogle Scholar
  3. 3.
    E. I. Budowsky et al., Biochim. Biophys. Acta, 122, 213, 1966.CrossRefGoogle Scholar
  4. 4.
    R. Caputto et al., J. Biol. Chem.,184, 333, 1950.PubMedGoogle Scholar
  5. 5.
    N. K. Kochetkov, E. I. Budovskii, and V. N. Shibaev, Izv. AN SSSR, OKhN, 1035, 1962.Google Scholar
  6. 6.
    J. T. Park and M. J. Johnson, J. Biol. Chem.,181, 149, 1949.PubMedPubMedCentralGoogle Scholar
  7. 7.
    C. A. Bunton, D. R. Llewellyn, K. G. Oldham, and C. A. Vernon, J. Chem. Soc., 3588, 1958.Google Scholar
  8. 8.
    T. E. Timell, Can. J. Chem.,42, 1456, 1964.CrossRefGoogle Scholar

Copyright information

© The Faraday Press, Inc. 1971

Authors and Affiliations

  • E. I. Budovskii
    • 1
  • V. N. Shibaev
    • 1
  1. 1.Institute of the Chemistry of Natural Compounds AS USSRUSSR

Personalised recommendations