Summary
Human papillomavirus (HPV) lesions in the skin are rejected by immunological mechanisms, but very little is known about such mechanisms in HPV lesions of the uterine cervix. We studied the mononuclear cell infiltrates in cervical biopsies from 65 women with an HPV lesion (flat, inverted or papillomatous condyloma) who were followed for at least twelve months. We examined cryostat sections using the ANAE (acid α-naphthylacetate esterase) technique to demonstrate B cell, T cells, and mononuclear phagocytes (MPs), and monoclonal antibodies (OKT3, OKT4, OKT6, and OKT8) for the T cell subsets. The percentages of B-, T-, and MPs in HPV lesions with concomitant cervical intraepithelial neoplasia (CIN) were similar to those lesions without CIN. Similarly, no significant differences in cell type percentages were found in HPV lesions which regressed (n=24), remained stationary (n=24) or progressed (n=3) during the follow-up period. The ratio OKT4+/OKT8+ (T helper/T suppressor, cytotoxic) cells was 1.44 and 0.81 in HPV lesions with CIN and those without CIN respectively (p<0.025). No statistically significant differences in that ratio were found between the lesions which remained stationary, regressed or progressed. The tendency to progress was directly related to the degree of CIN associated with HPV.
Similar content being viewed by others
References
Berman A, Winkelmann RK (1977) Flat warts undergoing involution. Arch Dermatol 113: 1219
Brodersen I, Genner J (1973) Histological and immunological observations on common warts in regression. Acta Dermatovener 53: 461
Chretien JH, Esswein JG, Garagusi VF (1978) Decreased T cell levels in patients with warts. Arch Dermatol 114: 213
Gliński W, Jablońska S, Langner A, Obalek S, Haftek M, Proniewska M (1976) Cell-mediated immunity in epidermodysplasia verruciformis. Dermatologica 153: 218
Gliński W, Obalek S, Jablońska S, Orth G (1981) T cell defect in patients with epidermodysplasia verruciformis due to Human papillomavirus type 3 and 5. Dermatologica 162: 141
Ingelfinger JR, Grupe WE, Topor M, Levey RH (1977) Warts in a pediatric renal transplant population. Dermatologica 155: 7
Ivanyi L, Morison WL (1976) In vitro lymphocyte stimulation by wart antigen in man. Br J Dermatol 94: 523
Jablońska S, Orth G, Lutzner MA (1982) Immunopathology of papillomavirus-induced tumors in different tissues. Springer Semin Immunopathol 5: 33
Knowles DM, Hoffman HT, Ferrarini M, Kunkel HG (1978) The demonstration of acid α-naphthyl acetate esterase activity in human lymphocytes: Usefulness as a T-cell marker. Cell Immunol 35: 112
Kossard S, Xenias SJ, Palestine RF, Scheen SR, Winkelmann RK (1980) Inflammatory changes in verruca vulgaris. J Cutan Pathol 7: 217
Kung PC, Goldstein G, Reinherz EL, Schlossman SF (1979) Monoclonal antibodies defining distinctive human T-cell surface antigens. Science 206: 347
Kung PC, Talle MA, DeMaria ME, Butler MS, Lifter J, Goldstein G (1980) Strategies for generating monoclonal antibodies defining human T lymphocyte differentiation antigens. Transplant Proc (Suppl 1) XII: 141
Lee AKY, Eisinger M (1976) Cell-mediated immunity (CMI) to human wart virus and wart-associated tissue antigens. Clin Exp Immunol 26: 419
Morison WL (1975) In vitro assay of immunity to human wart antigen. Br J Dermatol 93: 545
Morison WL (1975) Cell-mediated immune response in patients with warts. Br J Dermatol 93: 553
Obalek S, Gliński W, Haftek M, Orth G, Jablońska S (1980) Comparative studies on cell-mediated immunity in patients with different warts. Dermatologica 161: 73
Pyrhönen S (1978) Antibody response against human papilloma viruses. M.D. Thesis, University of Helsinki
Reid TMS, Fraser NG, Kernohan IR (1976) Generalized warts and immune deficiency. Br J Dermatol 95: 559
Reinherz EL, Schlossman SF (1980) The differentiation and function of human T lymphocytes. Cell 19: 821
Schlake W, Meyer EM, Grundmann E (1978) Histochemical identification of T and B areas in paraffin-embedded lymphoid tissuses by demonstration of α-naphthyl acetate esterase (ANAE) activity. Pathol Res Pract 163: 173
Syrjänen KJ (1979) Morphologic survey of the condylomatous lesions in dysplastic and neoplastic epithelium of the uterine cervix. Arch Gynecol 227: 153
Syrjänen KJ (1980) Current views on the condylomatous lesions in uterine cervix and their possible relationship to cervical squamous cell carcinoma. Obstet Gynecol Surv 35: 685
Syrjänen KJ, Heinonen UM, Kauraniemi T (1981) Cytological evidence of the association of condylomatous lesions with the dysplastic and neoplastic changes in uterine cervix. Acta Cytol 25: 17
Syrjänen KJ, Pyrhönen S (1982) Immunoperoxidase demonstration of human papilloma virus (HPV) in dysplastic lesions of the uterine cervix. Arch Gynecol 233: 53
Syrjänen KJ (1983) Human papillomavirus (HPV) lesions in association with cervical dysplasias and neoplasias. Obstet Gynecol 62: 617
Syrjänen KJ (1983) Immunocompetent cells in uterine cervical lesions of human papillomavirus (HPV) origin. Gynecol Obstet Invest 16: 327
Tagami H, Ogino A, Takigawa M, Imamura S, Ofuji S (1974) Regression of plane warts following spontaneous inflammation. A histopathological study. Br J Dermatol 90: 147
Tagami H, Takigawa M, Ogino A, Imamura S, Ofuji S (1977) Spontaneous regression of plane warts after inflammation. Arch Dermatol 113: 1209
Thivolet J, Hegazy MR, Viac J, Chardonnet Y (1977) An in vivo study of cell-mediated immunity in human warts. Acta Dermatovener 57: 317
Viac J, Staquet MJ, Miguet M, Chabanon M, Thivolet J (1978) Specific immunity of human papilloma virus (HPV) in patients with genital warts. Br J Vener Dis 54: 172
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Syrjänen, K., Väyrynen, M., Castrén, O. et al. The relation between the type of immunoreactive cells found in human papillomavirus (HPV) lesions of the uterine cervix and the subsequent behaviour of these lesions. Arch. Gynecol. 234, 189–196 (1984). https://doi.org/10.1007/BF00570755
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00570755