Cancer Chemotherapy and Pharmacology

, Volume 20, Issue 3, pp 265–266 | Cite as

High-dose VP-16 with intermediate-dose cytosine arabinoside in the treatment of relapsed acute nonlymphocytic leukemia

  • Hon Y. Chan
  • Frederick J. Meyers
  • Jerry P. Lewis
Short Communication VP-16, Cytosine Arabinoside, Nonlymphocytic Leukaemia


In a study of 11 adult patients with acute nonlymphocytic leukemia (ANLL), infusion therapy with high-dose VP-16 and intermediate-dose cytosine arabinoside was administered. Response was assessed with reference to bone marrow aspirations performed on days 1; 12, 13, or 14; and 21 of treatment. All 7 of the patients with ANLL in relapse achieved marrow hypoplasia, and 3 of them achieved complete response. LFTs were elevated in most patients but no evidence of hepatocellular necrosis was observed. It is concluded that the value of VP-16 in ANLL may have been underestimated in the past because of inadequate dosing.


Bone Marrow Leukemia Cancer Research Adult Patient Cytosine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



acute nonlymphocytic leukemia


chronic granulocytic leukemia






Ara-C, intermediate-dose Ara-C (500 mg/m2 for 12 doses)


Ara-C, high-dose Ara-C (3 g/m2 for 12 doses)


serum glutamic transaminase


lactic dehydrogenase


serum glutamic oxaloacetic transaminase


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Hon Y. Chan
    • 1
  • Frederick J. Meyers
    • 1
  • Jerry P. Lewis
    • 1
  1. 1.Department of Internal Medicine, Division of Hematology and OncologyUniversity of California, Davis Medical CenterSacramentoUSA

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