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Cancer Chemotherapy and Pharmacology

, Volume 20, Issue 3, pp 213–218 | Cite as

Towards an assessment of toxicity in the treatment of ovarian cancer

  • L. Dones
  • E. Wiltshaw
  • B. G. Birkhead
  • R. R. P. Jackson
Original Articles Toxicity, Ovarian Cancer

Summary

Using data from a randomised clinical trial of two platinum drugs at The Royal Marsden Hospital, London, a descriptive model of toxicity has been developed and tested. Toxicity manifests itself in reducing the effectiveness of different body processes; five were selected in this study as being most critical. The model summarises and combines data from these five sites in terms of a clinician's assessment of the associated risk to the patient. It is hoped that the approach will help clarify toxicity information for use in patient management decision-making and in the reporting of clinical trial results.

Keywords

Clinical Trial Platinum Ovarian Cancer Cancer Research Patient Management 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Keeney RL, Raiffa H (1976) Decisions with multiple objectives: preferences and value trade-offs. Wiley, New YorkGoogle Scholar
  2. 2.
    Pocock SJ (1983) Clinical trials. A practical approach. Wiley, New YorkGoogle Scholar
  3. 3.
    Wiltshaw E (1985) Ovarian trials at the Royal Marsden Hospital. Cancer Treat Rev 12 (Suppl A) 67–71Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • L. Dones
    • 2
  • E. Wiltshaw
    • 1
  • B. G. Birkhead
    • 2
  • R. R. P. Jackson
    • 2
  1. 1.Royal Marsden HospitalLondonUK
  2. 2.Clinical Operational Research Unit, Department of Statistical ScienceUniversity College LondonLondonEngland

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