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Cancer Chemotherapy and Pharmacology

, Volume 20, Issue 3, pp 198–202 | Cite as

Influence of PSK (Krestin) on resistance to infection ofPseudomonas aeruginosa in tumor-bearing mice

  • Takao Ando
  • Isamu Motokawa
  • Katsuo Sakurai
  • Yoshio Ohmura
  • Takayoshi Fujii
  • Kenichi Matsunaga
  • Chikao Yoshikumi
  • Kikuo Nomoto
Original Articles Pseudomonas Aeruginosa, Infection, Tumor Bearing Mice, Cyclophosphamide, PSK

Summary

C3H/He mice were inoculated withPseudomonas aeruginosa by various routes 1 day after X5563 transplantation or 4 days after cyclophosphamide (CY) administration. Administration of PSK (Krestin) i.p. or p.o. to the tumor-bearing mice or CY-treated tumor-bearing mice resulted in an increase in survival rates. ViableP. aeruginosa were inoculated i.v. on day 0 into mice inoculated with tumor cells on day -12 and vaccinated with killedP. aerouginosa on day -10, or into mice inoculated with tumor cell on day -15, treated with CY on day -14 and vaccinated on day -10. Resistance to infection, which is enhanced by vaccination, was depressed by tumor burden or treatment with CY, but such depression was prevented by PSK administration.

Keywords

Tumor Cell Survival Rate Cancer Research Cyclophosphamide Tumor Burden 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used

CY

cyclophosphamide

i.p.

intraperitoneally

s.c.

subcutaneously

p.o.

orally

i.v.

intravenously

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Takao Ando
    • 1
  • Isamu Motokawa
    • 1
  • Katsuo Sakurai
    • 1
  • Yoshio Ohmura
    • 1
  • Takayoshi Fujii
    • 1
  • Kenichi Matsunaga
    • 1
  • Chikao Yoshikumi
    • 1
  • Kikuo Nomoto
    • 2
  1. 1.Biomedical Research LaboratoriesKureha Chemical Industry Co., LtdTokyoJapan
  2. 2.Department of Immunology, Medical Institute for Bioregulation ResearchKyushu UniversityFukuokaJapan

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