Abstract
A 2-month-old boy underwent surgery for removal of a right temporal melanotic neuroectodermal tumor of infancy (MNTI). Histologically the tumor tissue showed signs of malignancy. The child was reexamined several times up to the age of 5 years. Neuroradiological evaluation showed no evidence of tumor recurrence or metastases. No resulting handicap was observed during neurological and psychological follow-up examination at the age of 5 years. Our findings confirm that surgical removal as the therapy of choice provides an excellent prognosis for this kind of tumor in spite of its histologically malignant appearance.
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References
Anagnostopoulos DI, Everard GJH (1972) Melanotic progonoma of the skull. J Neurol Neurosurg Psychiatry 35:88–91
Ashley DJB (1964) Melanotic “adamantinoma” of the skull. J Pathol Bacteriol 87: 179–181
Cohen BH, Handler MS, De Vivo DC, Garvin JH, Hays, AP, Carmel P (1988) Central nervous system melanotic neuroectodermal tumor of infancy: value of chemotherapy in management. Neurology 38:163–164
Cutler LS, Chaudhry AP, Topazian R (1981) Melanotic neuroectodermal tumor of infancy: an ultrastructural study, literature review, and reevaluation. Cancer 48:257–270
Dehner LP, Sibley RK, Sauk JJ, Vickers RA, Nesbit ME, Leonard AS, Waite DE, Neeley JE, Ophoven J (1979) Malignant melanotic neuroectodermal tumor of infancy. A clinical, pathologic, ultrastructural and tissue culture study. Cancer 43:1389–1410
Fowler M, Simpson DA (1962) A malignant melanin-forming tumour of the cerebellum. J Pathol Bacteriol 84:307–311
Hahn JF, Sperber EE, Netsky MG (1976) Melanotic neuroectodermal tumors of the brain and skull. J Neuropathol Exp Neurol 35:508–519
Johnson RE, Scheithauer BW, Dahlin DC (1983) Melanotic neuroectodermal tumor of infancy. A review of seven cases. Cancer 52:661–666
Koudstaal J, Oldhoff J, Panders AK, Hardonk MJ (1968) Melanotic neuroectodermal tumor of infancy. Cancer 22:151–161
Krompecher E (1918) Zur Histogenese und Morphologie der Adamantinome und sonstiger Kiefergeschwülste. Beitr Pathol Anat 64:165–197
Lindahl F (1970) Malignant melanotic progonoma. One case. Acta Pathol Microbiol Scand [A] 78:532–536
Mirich DR, Blaser SI, Harwood-Nash DC, Armstrong DC, Becker LE, Posnick JC (1991) Melanotic neuroectodermal tumor of infancy: clinical, radiologic, and pathologic findings in five cases. AJNR 12:689–697
Parizek J, Nemecek S, Cernoch Z, Heger L, Nozicka Z, Spacek J (1986) Melanotic neuroectodermal neurocranial tumor of infancy of extra-, intra-and subdural right temporal location: CT examination surgical treatment, literature review. Neuropediatrics 17:115–123
Russegger L, Weiser G, Grunert V (1987) Intrakranielle Manifestation eines sogenannten “melanotischen neuroektodermalen Tumors des Säuglingsalters” — ein Choristom mit Neuralleistenpotenzen. Wien Klin Wochenschr 99:647–652
Touwen BCL (1982) Die Untersuchung von Kindern mit geringen neurologischen Funktionsstörungen. Thieme, Stuttgart
Zimmer R, Volkamer M (1984) Motoriktest für 4–6jährige Kinder. Beltz, Weinheim
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Dammann, O., Hagel, C., Allers, B. et al. Malignant melanotic neuroectodermal tumor of infancy. Child's Nerv Syst 11, 186–188 (1995). https://doi.org/10.1007/BF00570263
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DOI: https://doi.org/10.1007/BF00570263