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Relative bioavailability of a paracetamol suppository

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Summary

The relative bioavailability of a new paracetamol suppository (Panodil) and tablets in doses of 0.5 and 1 g was investigated in eight healthy subjects. The tablets were absorbed faster and higher peak plasma concentrations were obtained than after the suppositories. The bioavailability of the suppositories was approximately 80% of that of the tablets at both dose levels. There was no indication of capacity-limited elimination at either the two doses investigated.

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Authors and Affiliations

  1. Departments of Clinical Pharmacology and Internal Medicine, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden

    P. Seideman, G. Alván, R. S. Andrews & A. Labross

  2. Sterling Winthrop, Research and Development Laboratories, Newcastle, UK

    P. Seideman, G. Alván, R. S. Andrews & A. Labross

Authors
  1. P. Seideman
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  2. G. Alván
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  3. R. S. Andrews
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  4. A. Labross
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Seideman, P., Alván, G., Andrews, R.S. et al. Relative bioavailability of a paracetamol suppository. Eur J Clin Pharmacol 17, 465–468 (1980). https://doi.org/10.1007/BF00570165

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  • DOI: https://doi.org/10.1007/BF00570165

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