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Archives of Toxicology

, Volume 62, Issue 2–3, pp 240–241 | Cite as

Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone

  • Akira Matsumoto
Short Communication

Abstract

We examined whether the bone resorption induced by PGE2 was inhibited by SrCl2 using45Ca-labelled calvaria of CD-strain mice in tissue culture. It was found that Sr salts inhibited physiological bone resorption in a dose-dependent manner (0.1–5.0 mM) and did not act via PGE2. Accordingly, it was suggested that Sr salts did not inhibit bone resorption induced by exogenous PGE2.

Key words

Prostaglandin E2 Strontium chloride Bone resorption 45CaCl2 Mouse calvaria 

Abbreviations

PGE2

Prostaglandin E2

PTH

Parathyroid hormone

CT

Calcitonin

Vit. D3

Vitamin D3

HSDM1

Harvard School of Dental Medicine 1

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Akira Matsumoto
    • 1
  1. 1.Department of Dental PharmacologySchool of Dentistry, Hokkaido UniversitySapporoJapan

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