Sodium ions increase the affinity of clonidine for α1-adrenoceptors in rat brain

  • Hartmut Glossmann
  • Rainer Hornung
  • Rita Schlusche
Article

Summary

α1-Adrenoceptors in rat brain membranes, labeled by the antagonist [3H] prazosin, increase their affinity for clonidine several-fold when sodium ions are added. The conversion of α1-adrenoceptors, by sodium ion, into a conformation, which has higher affinity for the agonist clonidine, indicates that these receptors as the α2-adrenoceptors are modulated by cations in vitro.

Key words

Prazosin Clonidine Sodium ions Brain membranes α1-Adrenoceptors 

References

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  3. Hornung, R., Presek, P., Glossmann, H.: Alpha adrenoceptors in rat brain. Direct identification with prazosin. Naunyn-Schmiedeberg's Arch. Pharmacol.308, 223–230 (1979)Google Scholar
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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Hartmut Glossmann
    • 1
  • Rainer Hornung
    • 1
  • Rita Schlusche
    • 1
  1. 1.Rudolf Buchheim-Institut für PharmakologieGiessenFederal Republic of Germany

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