Human Genetics

, Volume 60, Issue 2, pp 163–166 | Cite as

X-linked genes of the H-Y antigen system in the wood lemming (Myopus schisticolor)

  • Ulf Wiberg
  • Antonia Mayerová
  • Ulrich Müller
  • Karl Fredga
  • Ulrich Wolf
Original Investigations

Summary

H-Y antigen was investigated in 18 specimens representing six different sex chromosome constitutions of the wood lemming (Myopus schisticolor). The control range of H-Y antigen was defined by the sex difference between normal XX females (H-Y negativeper definitionem) and normal XY males (H-Y positive, full titer). H-Y antigen titers of the X*Y and X*0 females were in the male control range, while in the X*X and X0 females the titers were intermediary. Data were obtained with two different H-Y antigen assays: the Raji cell cytotoxicity test and the peroxidase-antiperoxidase (PAP) method. Fibroblasts, gonadal cells, and spleen cells were checked. Presence of full titers of H-Y antigen in the absence of testis differentiation is readily explained by the assumption of a deficiency of the gonadspecific receptor of H-Y antigen. Since sex reversal is inherited as an X-linked trait, genes for this receptor are most likely X-linked. The implications of our findings are discussed in connection with earlier findings concerning H-Y antigen in XY gonadal dysgenesis in man and the X0 situation in man and mouse.

Keywords

Raji Cell Control Range Gonadal Dysgenesis Antigen Titer Gonadal Cell 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Ulf Wiberg
    • 1
  • Antonia Mayerová
    • 2
  • Ulrich Müller
    • 2
  • Karl Fredga
    • 1
  • Ulrich Wolf
    • 2
  1. 1.Institute of GeneticsUniversity of LundLundSweden
  2. 2.Institut für Humangenetik und Anthropologie der Universität FreiburgFreiburg i. Br.Germany

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