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Exclusion of linkage between the loci for multiple endocrine neoplasia type-2 (MEN-2) and HLA

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Summary

Data from five nuclear families within a large kindred with multiple endocrine neoplasia type-2 (MEN-2) or Sipple's syndrome exclude linkage between the disease locus and the loci in the HLA complex. There were seven recombinants and seven non-recombinants in the four families with phase known data and total lod score of-2.659 for a recombination fraction of 0.1.

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Authors and Affiliations

  1. Department of Paediatrics, Queen's University, 20 Barrie Street, Kingston, Ontario, Canada

    Nancy E. Simpson

  2. Department of Biology, Queen's University, 20 Barrie Street, Kingston, Ontario, Canada

    Nancy E. Simpson

  3. Tissue Typing Laboratory, Toronto Western Hospital, Toronto, Ontario, Canada

    Judy Falk

Authors
  1. Nancy E. Simpson
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  2. Judy Falk
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Simpson, N.E., Falk, J. Exclusion of linkage between the loci for multiple endocrine neoplasia type-2 (MEN-2) and HLA. Hum Genet 60, 157 (1982). https://doi.org/10.1007/BF00569703

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  • DOI: https://doi.org/10.1007/BF00569703

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