Acta Diabetologica

, Volume 32, Issue 2, pp 131–134 | Cite as

Effect of recombinant human growth hormone treatment on insulin-like growth factor (IGF-I) levels in insulin-dependent diabetic patients

  • M. I. Wurzburger
  • G. M. Prelevic
  • P. H. Sönksen
  • M. Wheeler
  • L. Balint-Peric
Originals

Abstract

Basal and recombinant human growth hormone (rhGH)-stimulated insulin-like growth factor (IGF-I) levels were studied in 19 insulin-dependent diabetic patients and 4 healthy subjects. Diabetic patients were divided according to glucagon test result into CpN (10 patients without residual beta cell activity) and CpP (9 patients with preserved beta-cell activity) groups, and according to age into three groups (A=21–30 years; B=31–40 years; C=41–50 years). All control subjects belonged to group B. Blood glucose and growth hormone were measured at hourly intervals and IGF-I every 6 h during 24 h before and after 7 days treatment with 4 IU of rhGH given subcutaneously at 8 p.m. The age-related decrease in basal IGF-I levels was evident in both CpN and CpP groups of diabetic patients. IGF-I net increase with rhGH treatment was variable and insignificant in comparison with basal value without age-related differences in CpN diabetics. Progressively larger age-related increases in IGF-I concentrations were observed in CpP diabetic patients. This study indicates impairment of hepatic IGF-I generation capacity in diabetic patients without residual beta-cell activity and the importance of simultaneous actions of portal insulin and GH on hepatic IGF-I production.

Key words

Type I diabetes mellitus Human recombinant growth hormone Insulin-like growth factor I Residual beta-cell activity 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • M. I. Wurzburger
    • 1
  • G. M. Prelevic
    • 1
  • P. H. Sönksen
    • 2
  • M. Wheeler
    • 3
  • L. Balint-Peric
    • 1
  1. 1.Endocrinology Department‘Zvezdara’ University Medical CentreBelgrade, BelgradeYugoslavia
  2. 2.Department of Medicine, United Medical and Dental Schools of Guy's and St. Thomas' HospitalSt. Thomas' HospitalLondonUK
  3. 3.Chemical Pathology, United Medical and Dental Schools of Guy's and St. Thomas' HospitalSt. Thomas' HospitalLondonUK

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