Acta Diabetologica

, Volume 32, Issue 2, pp 110–115 | Cite as

Diastolic dysfunction is not related to changes in glycaemic control over 6 months in type 2 (non-insulin-dependent) diabetes mellitus

A cross-sectional study
  • S. C. L. Gough
  • J. Smyllie
  • M. Barker
  • K. E. Berkin
  • P. J. S. Rice
  • P. J. Grant


Diastolic dysfunction may be the earliest marker of a diabetes-induced heart muscle disease which leads to the progressive development of cardiac failure. Left ventricular diastolic function was indirectly assessed using pulsed wave Doppler ultrasound mitral-flow velocities in 20 normotensive patients with a new diagnosis of type 2 diabetes mellitus, normal cardiac function and no evidence of coronary artery disease and in 16 age-matched normal subjects. Peak velocities of early (E) and late (A) left ventricular filling were measured. The median (interquartile ranges) peak E/A ratio was significantly reduced in the diabetic group 0.96 (0.8–1.2) vs 1.2 (1.1–1.3),P<0.01. Despite improvements in glycaemic control over 3 months, HbA1c 9.9% (7.6%–10.5%) to 7.4% (6.5%–7.9%),P<0.001, maintained at 6 months, HbA1c 7.0% (6.4%–7.3%), there were no changes in the E/A ratio, 0.96 (0.83–1.15) and 0.95 (0.83–1.17), respectively. Furthermore, there was no correlation between percentage change in HbA1c and E/A ratio over 6 months. The results of this study suggest that in patients with type 2 diabetes mellitus and normal systolic function, diastolic function was impaired at diagnosis and was not affected by an improvement in the glycaemic control.

Key words

Cardiac function Glycaemic control Diabetes type 2 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • S. C. L. Gough
    • 1
  • J. Smyllie
    • 2
  • M. Barker
    • 3
  • K. E. Berkin
    • 2
  • P. J. S. Rice
    • 1
  • P. J. Grant
    • 1
  1. 1.Diabetes and Thrombosis Research GroupUniversity of LeedsLeedsUK
  2. 2.Department of CardiologyThe General InfirmaryLeedsUK
  3. 3.Medical PhysicsThe General InfirmaryLeedsUK

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