Abstract
Recent data suggest that in a proportion of NIDDM patients there is a slowly evolving insulitis which results in a latent autoimmune diabetes leading to full insulin-dependence. Many animal models exist of NIDDM but none have reported the spontaneous existence of a similar phenomenon. We have re-examined the histology of pancreata from a few Psammomys obesus who had become insulin-dependent in the late stages of NIDDM. We report here the unexpected finding of the presence of insulitis in these animals and suggest that they could be a model for the clinical observation of latent IDDM in NIDDM patients.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Editorial, Insulin-dependent? Lancet II:809–810, 1985
Groop LC, Bottazzo GF, Doniach D, Islet cell antibodies identify latent type I diabetes in patients aged 35–75 years at diagnosis. Diabetes 35: 237–241, 1986
Irvine WJ, Gray RS, McCallum CJ, Duncan LJP, Clinical and pathogenic significance of pancreatic-islet-cell antibodies in diabetics treated with oral hypoglycaemic agents. Lancet I: 1025–1027, 1977
Groop LC, Miettinen A, Groop P, Meri S, Koskimies S, Bottazzo GF, Organ-specific autoimmunity and HLA-DR antigens as markers for β-cell destruction in patients with type II diabetes. Diabetes 37: 99–103, 1988
Tuomi T, Groop LC, Zimmet PZ, Rowley MJ Knowles W, Mackay IR, Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non insulin-dependent onset of disease. Diabetes 42: 359–362, 1993
Marquié G, Duhault J, Jacotot B, Diabetes mellitus in sand rats (Psammomys obesus). Diabetes 33:438–443, 1984
Petkov P, Hadjiisky P, Marquié G, Pancreatic islets histochemistry in normal sand rats (Psammomys obesus). Cell Mol Biol 27: 655–665, 1981
Petkov P, Marquié G, Donev S, Dhamani Y, Duhault J, Morphology of the endocrine pancreas in diabetic sand rat (Psammomys obesus). Cell Mol Biol 31: 61–74, 1985
Crisa L, Mordes JP, Rossini AA, Autoimmune diabetes mellitus in the BB rat. Diabetes Metab Rev 8: 4–37, 1992
Kolb H, Mouse models of insulin dependent diabetes: low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice. Diabetes Metab Rev 3: 751–778, 1987
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Duhault, J., Boulanger, M., Espinal, J. et al. Latent autoimmune diabetes mellitus in adult humans with non-insulin-dependent diabetes: isPsammomys obesus a suitable animal model?. Acta Diabetol 32, 92–94 (1995). https://doi.org/10.1007/BF00569564
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00569564