Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 334, Issue 4, pp 346–351 | Cite as

Cholinergic but not monoaminergic denervation increases nerve growth factor content in the adult rat hippocampus and cerebral cortex

  • G. Weskamp
  • H. P. Lorez
  • H. H. Keller
  • U. Otten


We have investigated whether degeneration of basal forebrain cholinergic neurons is a potential trigger for increased NGF production in the adult rat brain. Electrolytic lesions of cholinergic neurons in the septum-diagonal band and in the nucleus basalis of Meynert induced a transient increase in NGF in the ventral hippocampus (+70%) and cerebral cortex (+125%), respectively. In contrast, selective aminergic denervation of the forebrain by electrolytic lesion of the medial forebrain bundle, did not increase NGF levels in hippocampus and cerebral cortex. Thus, a cholinergic mechanism appears to regulate NGF production in adult rat basal forebrain.

Key words

Nerve growth factor (NGF) Rat basal forebrain Cholinergic neurons Monoaminergic neurons Denervation 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • G. Weskamp
    • 1
  • H. P. Lorez
    • 2
  • H. H. Keller
    • 2
  • U. Otten
    • 1
  1. 1.Department of PharmacologyBiocenter of the UniversityBaselSwitzerland
  2. 2.Pharmaceutical Research DepartmentF. Hoffmann-La Roche & Co., Ltd.BaselSwitzerland

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