Summary
Small mammary isografts from tritiated thymidine pretreated donors became disorganized within 24 hours of transplantation; isotope-labelled cells were dispersed in the mammary fat pad. At 72 hours after transplantation some aggregates of mammary cells were organized into mammary ducts with one or more epithelial cell layers. At 96 hours all stages occurred in individual transplants that were often disconnected, but only one mammary gland eventually developed from each graft.
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Supported by grants from the National Cancer Institute of Canada, the Medical Research Council of Canada and the Jane Coffin Childs Memorial Fund for Medical Research.
The authors are indebted to Mrs. Sharon Griffin for her technical assistance.
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Chew, E.C., Hoshino, K. Early histogenesis of transplanted mouse mammary glands. Z. Anat. Entwickl. Gesch. 132, 318–324 (1970). https://doi.org/10.1007/BF00569269
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DOI: https://doi.org/10.1007/BF00569269